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Neuroimagem Funcional Usando rompimento da barreira hemato-encefálica ultra-sônico e Manganês-RM

Article DOI: 10.3791/4055-v • 08:36 min • July 12th, 2012
July 12th, 2012 •
1, 2, 3, 3, 2
1Department of Radiology, Stanford University, 2Center for In Vivo Microscopy, Duke University Medical Center, 3Department of Biomedical Engineering, Duke University

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Uma técnica é descrita para amplamente abertura da barreira sangue-cérebro no ratinho usando microbolhas e ultra-som. Usando esta técnica, o manganês pode ser administrada para o cérebro do rato. Porque o manganês é um agente de contraste para IRM que se acumula nos neurónios despolarizadas, esta abordagem permite imagiologia de actividade neuronal.

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Neuroscience Biologia Molecular Engenharia Biomédica mouse ultra-som a barreira sangue-cérebro a ressonância magnética funcional fMRI manganês-RM MEMRI
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