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Journal / Neuroscience / Generering av Topically Transgene Rats etter
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Neuroscience

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Generering av Topically Transgene Rats etter

Article DOI: 10.3791/50146-v • 08:44 min • September 24th, 2013
September 24th, 2013 •
1, 2, 2, 3, 1
1Department of Neuropathology, Medical School Düsseldorf, 2Department of Molecular Genetics, Weizmann Institute for Science, 3Center of Behavioral Neuroscience, University of Düsseldorf

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Gener kan manipuleres under utviklingen av hjernebarken eller hippocampus av rotte via in utero electroporation (iue) på E16, for å muliggjøre rask og målrettede endringer i nevronale tilkobling for senere studier av atferd eller nevropatologi hos voksne dyr. Postnatal in vivo avbildning for kontroll av IUE suksess er utført av bioluminescens for aktivering co-transfektert luciferase.

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Neuroscience Hippocampus Memory schizofreni, Luciferase Disrupted-in-schizofreni-en (DISC1)
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