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Journal / Neuroscience / Direkte Intraventrikulær Delivery of Drugs til…
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Neuroscience

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JoVE Journal Neuroscience
Direkte Intraventrikulær Delivery of Drugs til Rodent centrale nervesystem
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Direkte Intraventrikulær Delivery of Drugs til Rodent centrale nervesystem

Article DOI: 10.3791/50326-v • 14:55 min • May 12th, 2013
May 12th, 2013 •
1, 1
1Department of Neurology, Washington University in St. Louis School of Medicine

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Vi beskriver en metode til at målrette lægemidler til centralnervesystemet ved enten at implantere et kateter eller udfører en bolus injektion i højre laterale ventrikel i mus. Vi fokuserer specifikt på levering af antisense oligonukleotider. Denne teknik kan let tilpasses til andre stoffer og til rotter.

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Neurobiologi Neuroscience medicin Biomedical Engineering Genetik anatomi fysiologi kirurgi farmakologi cerebrospinalvæske Rodentia Oligonukleotider Antisense Drug Administration Routes injektioner intraventrikulært Drug Delivery Systems mus rotter hjerne antisense oligonukleotid osmotisk pumpe bolus ventrikel Neurosciences Translationel cerebrospinalvæske CNS kanyle kateter dyremodel kirurgiske teknikker
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