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Der Ansatz kombiniert ChroP ChIP und Massenspektrometrie zu sezieren Locus-spezifische Proteomik Landschaften des Chromatin
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Der Ansatz kombiniert ChroP ChIP und Massenspektrometrie zu sezieren Locus-spezifische Proteomik Landschaften des Chromatin

Article DOI: 10.3791/51220-v • 24:02 min • April 11th, 2014
April 11th, 2014 •
1, 1
1Department of Experimental Oncology, European Institute of Oncology

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Durch die Kombination von nativen und Vernetzungs Chromatinimmunpräzipitation mit hochauflösender Massenspektrometrie ermöglicht ChroP Ansatz, um die Verbund Proteom-Architektur der Histon-Modifikationen, Varianten und Nicht-Histon-Proteine ​​synergizing bei funktionell unterschiedlichen Chromatindomänen sezieren.

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Biochemie Chromatin Histon-post-translationale Modifikationen (hPTMs) Epigenetik Massenspektrometrie Proteomics SILAC Chromatinimmunpräzipitation Histon-Varianten chromatome hPTMs Quer Gespräche
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