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Journal / Neuroscience / Anpassning av mikroelektrod Array teknik för…
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Neuroscience

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JoVE Journal Neuroscience
Anpassning av mikroelektrod Array teknik för studier av anestesi-inducerad neurotoxicitet i intakt Nasse hjärnan
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Anpassning av mikroelektrod Array teknik för studier av anestesi-inducerad neurotoxicitet i intakt Nasse hjärnan

Article DOI: 10.3791/57391-v • 08:23 min • May 12th, 2018
May 12th, 2018 •
*1, *1, *1, *1,2, *1,2, *1,3, 1, 4, 4, 4, 1,3
1Department of Anesthesiology, Ohio State University College of Medicine, 2Medical Student Research Program, Ohio State University College of Medicine, 3Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, 4Department of Neuroscience, University of Kentucky Medical Center
* These authors contributed equally

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Denna studie undersöker roman användningen av enzym-baserade mikroelektrod array (MEA) teknik för att övervaka i vivo signalsubstans aktivitet hos smågrisar. Hypotesen var att glutamat dysreglering bidrar till mekanismen av bedövningsmedel neurotoxicitet. Här presenterar vi ett protokoll för att anpassa MEA teknik för att studera mekanismen för anestesi-inducerad neurotoxicitet.

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Neurovetenskap fråga 135 Glutamat hippocampus neurotransmittorer neuroinflammation neuroutvecklingssjukdomar sevofluran pediatrisk anestesi
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