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Chemistry

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JoVE Journal Chemistry
Solid fase 11C-methylering, oprensning og formulering til fremstilling af PET-Tracers
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Solid fase 11C-methylering, oprensning og formulering til fremstilling af PET-Tracers

Article DOI: 10.3791/60237-v • 09:25 min • October 24th, 2019
October 24th, 2019 •
*1, *1, 1, 1, 1, 1,2
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 2Department of Neurology and Neurosurgery, McGill University
* These authors contributed equally

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Vi rapporterer en effektiv Carbon-11 radiolabeling teknik til at producere klinisk relevante røbestoffer til Positron emission Tomography (PET) ved hjælp af solid Phase ekstraktions patroner. 11 C-methylerende middel passerer gennem en cylinderampul, der er forudindlæst med forløber, og efterfølgende eluering med vandig ethanol giver kemisk og radiokemisk ren PET-røbestoffer i høje radiokemiske udbytter.

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Kemi Carbon-11 radioaktiv mærkning Positron emission Tomography Imaging [11c] PIB [11c] ABP688 11c-methylering solid fase understøttet syntese solid fase ekstraktion automatisering
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