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Immunology and Infection

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Análisis de la permeabilidad de la barrera hematoencefálica mediante travesía microbiana a través de células endoteliales microvasculares

Article DOI: 10.3791/60692-v • 06:26 min • February 14th, 2020
February 14th, 2020 •
1, 1, 1, 1
1Institute of Physiological Chemistry, Martin Luther University Halle-Wittenberg

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La barrera hematoencefálica humana previene selectivamente la penetración de moléculas hidrófilas y patógenos en el cerebro. Varias patologías, incluyendo meningitis y delirio postoperatorio, se asocian con una mayor permeabilidad de la barrera hematoencefálica. Aquí, describimos un modelo de cultivo celular endotelial para probar la permeabilidad de barrera por travesía microbiana.

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Inmunología e infección número 156 travesario bacteriano barrera hematoencefálica adherencia celular cribado compuesto células endoteliales inflamación meningitis permeabilidad celular delirio postoperatorio uniones estrechas células endoteliales microvasculares cerebrales
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