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Chemistry

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JoVE Journal Chemistry
Instrueret samling af elastin-lignende proteiner i definerede supramolekylære strukturer og cargo indkapsling in Vitro
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Instrueret samling af elastin-lignende proteiner i definerede supramolekylære strukturer og cargo indkapsling in Vitro

Article DOI: 10.3791/60935-v • 10:01 min • April 8th, 2020
April 8th, 2020 •
*1,2, *1,2, 1,2, 1,2, 1,2,3,4,5,6
1Center for Biological Systems Analysis, University of Freiburg, 2Faculty of Biology, University of Freiburg, 3Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, 4BIOSS Centre for Biological Signalling Studies, University of Freiburg, 5IMTEK Department of Microsystems Engineering, University of Freiburg, 6Cluster of Excellence livMatS at FIT - Freiburg Center for Interactive Materials and Bioinspired Technologies, University of Freiburg
* These authors contributed equally

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På grænsefladen af organiske og vandige opløsningsmidler samles skræddersyede amfifile elastin-lignende proteiner i komplekse supramolekylære strukturer såsom vesikler, fibre og coacervater udløst af miljømæssige parametre. De beskrevne montageprotokoller giver Protein Membrane-Based Compartments (PMBC' er) med tunable-egenskaber, hvilket muliggør indkapsling af forskellige laster.

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Kemi elastin-lignende proteiner proteinbaserede vesikler proteinfibre lægemiddelfremføringssystemer selvsamling proteinmembran
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