Ultra-high Field
Ultra-high Field - Related Videos
07:35
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Cited by 14 •
2015
The use of ultra-high field MRI as a non-invasive way to obtain phenotypic information of rodent models for polycystic kidney disease and to monitor interventions is described. Compared with the traditional histological approach, MRI images can be acquired in vivo, allowing for longitudinal follow-up.
08:53
Angle-resolved Photoemission Spectroscopy At Ultra-low Temperatures
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Cited by 8 •
2012
The overall goal of this method is to determine the low-energy electronic structure of solids at ultra-low temperatures using Angle-Resolved Photoemission Spectroscopy with synchrotron radiation.
05:04
Determining the Mechanical Strength of Ultra-Fine-Grained Metals
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2021
The protocol presented here describes the high-pressure radial diamond-anvil-cell experiments and analyzing the related data, which are essential for obtaining the mechanical strength of the nanomaterials with a significant breakthrough to the traditional approach.
07:51
Fabrication of Silica Ultra High Quality Factor Microresonators
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Cited by 22 •
2012
We describe the use of a carbon dioxide laser reflow technique to fabricate silica resonant cavities, including free-standing microspheres and on-chip microtoroids. The reflow method removes surface imperfections, allowing long photon lifetimes within both devices. The resulting devices have ultra high quality factors, enabling applications ranging from telecommunications to biodetection.
05:28
MALDI Sample Preparation: the Ultra Thin Layer Method
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Cited by 32 •
2007
This video demonstrates the preparation of an ultra-thin matrix/analyte layer for analyzing peptides and proteins by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI-MS).
FAQs
The static field increases the Zeeman energy separation between nuclear spin states. That larger separation produces greater nuclear spin polarization, so more spins contribute to a measurable signal. In practice, this can improve sensitivity in nuclear magnetic resonance and magnetic resonance imaging, helping investigators detect features or molecular information that may be difficult to observe at lower fields.
Increasing field strength can improve signal strength and resolution, but it also makes experimental imperfections more consequential. Radiofrequency inhomogeneity can create uneven excitation or detection, susceptibility effects can distort measurements, and tissue heating can limit biological studies. Researchers therefore balance the benefits of enhanced sensitivity against field-specific constraints when designing experiments.
Compared with conventional field strengths, ultra-high field operation provides greater Zeeman energy separation, stronger nuclear spin polarization, and potentially more sensitive measurements. These advantages can reveal physical, molecular, or biological features that remain difficult to observe at lower fields. The comparison is therefore not simply about signal magnitude, because field-related inhomogeneity, susceptibility, and heating also become important.
A successful experiment must account for the static field’s effect on polarization while controlling radiofrequency uniformity, susceptibility-related changes, and tissue heating where biological samples are involved. These conditions influence signal quality, resolution, and experimental limits. Managing them is essential for converting the increased physical sensitivity of the system into interpretable measurements.
The approach supports high-resolution brain imaging, nuclear magnetic resonance spectroscopy, materials research, and investigations of molecular structure and dynamics. Its increased sensitivity can help distinguish features that are difficult to measure at lower fields. The appropriate application depends on whether the experiment prioritizes anatomical detail, spectroscopic information, material behavior, or molecular-level characterization.
Ultra-high field experiments provide a platform for precision measurement of matter, energy, and biological systems. In spectroscopy and materials studies, the enhanced response can support investigations of molecular structure and dynamics, while imaging applies related physical principles to complex biological systems. These measurements extend experimental access to properties that lower-field methods may not resolve.