Name: Otimizando técnicas de fotoneuromodulação para avaliar o papel dos diodos emissores de luz verde no controle da dor (Vídeo) | JoVE Journal
Uploaded: 2025-03-28T14:30:00.000+00:00
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Description: Aprenda técnicas de fotoneuromodulação com diodos emissores de luz verde para avaliar o controle da dor em modelos pré-clínicos e clínicos. Este método padroniza parâmetros de exposição para pesquisas reprodutíveis.

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</ol>

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otimizando técnicas de fotoneuromodulação para avaliar o papel dos diodos emissores de luz verde no controle da dor

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management

A exposição à luz verde aumenta as latências de retirada da pata de maneira dose-dependente 
A Figura 1A demonstra que a exposição a diodos emissores de luz verde (GLED) em várias intensidades (4, 50, 100 e 200 lux) aumentou significativamente as latências de retirada da pata em um modelo de rato ingênuo durante um período de exposição de 7 dias, indicando um efeito antinociceptivo do GLED. As latências basais antes da exposição à luz fora...

Otimizando técnicas de fotoneuromodulação para avaliar o papel dos diodos emissores de luz verde no controle da dor

Despite extensive research and the identification of numerous analgesic targets, the range of pharmacological treatments available for pain remains ...

optimizing-photoneuromodulation-techniques-to-evaluate-role-green

Research

JoVE Journal

Medicine

Medicina

Adulto-nascido neurônios expressando ChR2 pode ser manipulado em preparações fatia eletrofisiológicos, a fim de examinar sua contribuição para a função olfativa de circuitos neurais.

Acessível usando Arrays LED para Foto Estimulação de Neurônios

Neurônios adultos-nascido do bulbo olfativo pode ser controlado usando optogenetically Channelrhodopsin2 expressando injeção lentiviral no fluxo migratório rostral e fotoestimulação crônica com uma miniatura implantado LED.

Transdução Viral seletiva de Adultos-nascido neurônios olfativos de crônica In vivo Estímulo Optogenetic

Fonte: Zhang, L., et al. A luz infravermelha próxima (NIr) aumenta a expressão de um marcador da função mitocondrial no epitélio sensorial vestibular do camundongo. J. Vis. Exp. (2015)Este vídeo demonstra o processo de aplicação de luz NIr ao couro cabeludo de um camundongo raspado para ativar os neurônios vestibulares e estimular a produção de superóxido dismutase-1 (SOD-1), apoiando a função neuronal. O procedimento destaca a terapia NIr como uma estratégia neuroprotetora.

Modulando a sinalização neuronal sensorial em um modelo de camundongo usando luz infravermelha próxima

A optogenética tornou-se uma ferramenta poderosa para uso em experimentos de neurociência comportamental. Este protocolo oferece um guia passo a passo para o projeto e configuração de sistemas de laser e fornece um protocolo completo para a realização de estímulos optogenéticos in vivo múltiplos e simultâneos compatíveis com a maioria dos paradigmas de teste comportamental de roedores.

In vivo Optogenetic estimulação do sistema nervoso central de roedores

A luz de xenônio não coerente foi passada através de interferência de banda estreita e filtros de densidade neutra para fornecer luz de comprimento de onda e intensidade variados para células cultivadas. Este protocolo foi usado para avaliar os efeitos da terapia com luz vermelha / infravermelha próxima na produção de espécies reativas in vitro: nenhum efeito foi observado usando os parâmetros testados.

Método de Avaliação de efeitos de uma gama de comprimentos de onda e intensidades de Terapia da Luz Vermelha / near-infrared sobre o estresse oxidativo In Vitro

Este protocolo descreve como usar o aquecimento transitório associado à absorção óptica de nanobastões de ouro para estimular a diferenciação e a atividade intracelular de cálcio em células neuronais. Esses resultados potencialmente abrem novas aplicações em próteses neurais e estudos fundamentais em neurociência.

Ouro nanorod assistida estimulação óptica de Neuronal Cells

Um método para estimulação da atividade elétrica de culturas de células in vitro com luz visível é descrito.

Controle óptico de células vivas atividade elétrica por conjugados Polymers

Aqui, apresentamos o método de fabricação de um sistema optrode com fibras ópticas para entrega de luz e uma matriz de eletrodos para gravação neural. Experimentos in vivo com camundongos transgênicos expressando channelrhodopsin-2 mostram a viabilidade do sistema para estimulação optogenética simultânea e gravação eletrofisiológica.

Oprode Array para modulação optogenética simultânea e gravação neural elétrica

Aqui, descrevemos um dispositivo novo, simples e de baixo custo para realizar com sucesso ensaios de terapia fotodinâmica in vitro (TFD) usando cultura de células HeLa bidimensionais e verteporfina como fotossensibilizador.

Um dispositivo de terapia fotodinâmica interno construído internamente e baseado em diodo emissor de luz para melhorar a citotoxicidade da verteporfina em um modelo de cultura de células 2D

Este estudo apresenta a tecnologia não invasiva e portátil de fotobiomodulação transcraniana sob controle eletroencefalográfico para estimulação da remoção linfática de toxinas (por exemplo, beta-amiloide solúvel) do cérebro de camundongos machos BALB/c idosos e não anestesiados durante o sono profundo natural.

Fotobiomodulação sob controles eletroencefalográficos do sono para estimulação da remoção linfática de toxinas do cérebro de camundongos

Aqui, apresentamos um método para avaliar a ativação e o bloqueio dos axônios sensoriais nos nervos periféricos em experimentos agudos, anestesiados e in vivo com ratos, utilizando dois tipos de medições eletrofisiológicas da coluna vertebral que podem discriminar a atividade dos subtipos de fibras nervosas: Potenciais de Campo Local e registros de neurônios únicos em Faixa Dinâmica Ampla.

Métodos eletrofisiológicos para avaliar o bloqueio de dor periférica em um rato anestesiado

Aprenda técnicas de fotoneuromodulação com diodos emissores de luz verde para avaliar o controle da dor em modelos pré-clínicos e clínicos. Este método padroniza parâmetros de exposição para pesquisas reprodutíveis.

Otimizando técnicas de fotoneuromodulação para avaliar o papel dos diodos emissores de luz verde no controle da dor

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