Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove

26.9: Microtubules in Cell Motility

JoVE Core
Cell Biology

A subscription to JoVE is required to view this content. Sign in or start your free trial.

Microtubules in Cell Motility

26.9: Microtubules in Cell Motility

Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and body. The central strand of the flagellum is called the axoneme and has a 9+2 arrangement of microtubules.

Microtubules help cells move using mechanisms like modulating actin polymerization by regulating Rho GTPase signaling pathways. During actin polymerization, with the help of +TIPs complex, microtubules sequester signaling molecules and actin assembly factors. These molecules are only released upon the disassembly of microtubules, thus regulating lamellipodia and filopodia formation.

Microtubules can also regulate directional migrations when they act as tracks for motor proteins to transport intracellular cargo and signaling molecules to the leading edge of the migrating cells. The cortical microtubules associated with the focal adhesion junctions help recycle focal adhesion proteins from the cell membrane during cell motility. They also facilitate the cross-talk between different cytoskeletal components. These microtubules undergo repeated cycles of rescue and catastrophe near the cell boundaries to regulate cell motility.

Suggested Reading


Microtubules Cell Motility Cytoskeleton Cilia Flagella Basal Bodies Transition Zone Axoneme Actin Polymerization Rho GTPase Signaling Pathways +TIPs Complex Lamellipodia Filopodia Formation Directional Migrations Motor Proteins Intracellular Cargo Signaling Molecules Cortical Microtubules Focal Adhesion Junctions

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter