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17.16: Golgi Matrix Proteins

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Cell Biology

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Golgi Matrix Proteins

17.16: Golgi Matrix Proteins

Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.

One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi matrix proteins have been discovered, such as Golgi reassembly stacking proteins (GRASPs) and golgins.

GRASPs are peripheral membrane proteins on the cytoplasmic side of the Golgi cisternae that glue together adjacent cisternae like a ribbon. They form oligomers in the tight gaps between cisternae and are regulated by phosphorylation. During cell division, phosphorylation and dephosphorylation of these proteins help in Golgi stack disassembly and reassembly. Additionally, they participate in various cellular processes such as cargo-specific transport, apoptosis, regulation of cell cycle, and microtubule organization.

Golgins are peripheral proteins containing coiled-coil domains anchored on the Golgi membrane. The coiled-coil domains allow them to tether the membranes even over relatively long distances. Flexible regions between the coiled coils allow conformational changes while bringing two membranes close in the stack. Thus, they play a crucial role in maintaining the Golgi structure.

Suggested Reading


Golgi Matrix Proteins Stacked Structure Of Golgi Golgi Unstacking Golgi Reassembly GM130 GRASPs Golgins Peripheral Membrane Proteins Cisternae Phosphorylation Cargo-specific Transport Apoptosis Cell Cycle Regulation Microtubule Organization

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