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18.16: Determinación del plano de división celular

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Molecular Biology

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Determining the Plane of Cell Division

18.16: Determining the Plane of Cell Division

Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 

Animal cells

In animal cells, the cleavage furrow forms along the plane of cell division starting from the cell cortex, the region below the plasma membrane. The mitotic spindle plays a decisive role in determining the cell division plane; therefore, a change in the axis of the mitotic spindle can alter the division plane. This strategy is used by some eukaryotic organisms, such as Caenorhabditis elegans, to switch from symmetric to asymmetric cell division. Symmetric cell division produces two identical daughter cells and is often used to grow tissues containing many of the same cell type. In contrast, asymmetric division creates cellular diversity as it generates two non-identical daughter cells. For example, neuroepithelial cells initially increase their numbers by undergoing symmetric divisions. After which, they use asymmetric division to produce daughter cells similar to the parent cell as well as differentiating neurons.


In budding yeast, such as Saccharomyces cerevisiae, the plane of cell division is decided in the  G1 phase by septin proteins. Cytokinesis is achieved by forming a cleavage furrow at the neck region of the budding yeast cells; however, the mitotic apparatus does not play any role in determining the plane of cell division. In contrast, in fission yeast, such as Schizosaccharomyces pombe, the position of the interphase nucleus decides the location of the plane of cell division in the G2 phase. During interphase, the Mid1 protein is mainly localized in the nucleus; however, during mitosis, Mid1 is exported from the nucleus to the cell cortex, where it recruits actomyosin ring components to the medial region of the cell. This eventually results in the mother cell dividing into two similar-sized daughter cells.


In most plant cells, the plane of cell division is decided before the cell commits to mitosis. A preprophase band is formed along the equator of the parent cell, which marks the plane of cell division. The preprophase band is a ring-like structure composed of microtubules and F-actin. It gives rise to a microtubule bundle called the phragmoplast, which provides a structural scaffold for cell plate expansion and positioning.

Lectura sugerida


Plane Of Cell Division Mitosis Daughter Cells Cleavage Furrow Cell Cortex Plasma Membrane Mitotic Spindle Symmetric Division Asymmetric Division Cellular Diversity Neuroepithelial Cells Budding Yeast Saccharomyces Cerevisiae

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