Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove

16.15: Cycloaddition Reactions: Overview

JoVE Core
Organic Chemistry

A subscription to JoVE is required to view this content.
You will only be able to see the first 20 seconds.

Cycloaddition Reactions: Overview

16.15: Cycloaddition Reactions: Overview

Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.


The feasibility of cycloaddition reactions under thermal and photochemical conditions can be predicted using a set of selection rules. If the total number of π electrons involved in the rearrangement is a multiple of 4n, the reaction is photochemically allowed. The reaction is thermally allowed if the total number of π electrons involved is 4n + 2.

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter