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40.6: Lineage Commitment

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Cell Biology

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Lineage Commitment

40.6: Lineage Commitment

Commitment is the  process whereby stem cells:

  1.  lose their ability to form all cell types and
  2. irreversibly change into a specific type.

The multipotent hematopoietic stem cells, (HSCs), differentiate into the multipotent hematopoietic progenitor cells,  (HPCs). The HPCs express many lineage-specific cytokine receptors. Each of these receptors binds specific cytokines, activates distinct signaling pathways, and expresses a particular gene set. The HPCs further differentiate to form committed progenitors, forming either  common myeloid progenitors (CMPs) or common lymphoid progenitors (CLPs). The CMPs and CLPs proliferate, self-renew, and further differentiate into mature blood cells and immune cells depending on the receptors they express and the specific cytokines that bind. For example:

  • Thrombopoietin (TpoR)- They help progenitors differentiate into megakaryocytes or platelets.
  • Erythropoietin (EpoR)-These receptors promote the development of erythrocytes.
  • Macrophage-colony stimulating factor (M-CSFR)-These receptors regulate the formation of macrophages.
  • Granulocyte-colony stimulating factor (G-CSFR)- They help HPCs differentiate into granulocytes.
  • Interleukin-7 receptor (IL-7R)- They help progenitor cells become lymphocytes.

Thus, lineage commitment helps HSCs lose their multipotency and differentiate into more restricted cell fate.

Suggested Reading


Lineage Commitment Stem Cells Cell Types Specific Type Hematopoietic Stem Cells (HSCs) Hematopoietic Progenitor Cells (HPCs) Cytokine Receptors Signaling Pathways Gene Set Committed Progenitors Common Myeloid Progenitors (CMPs) Common Lymphoid Progenitors (CLPs) Blood Cells Immune Cells Thrombopoietin (TpoR) Erythropoietin (EpoR) Macrophage-colony Stimulating Factor (M-CSFR) Granulocyte-colony Stimulating Factor (G-CSFR) Interleukin-7 Receptor (IL-7R) Multipotency Restricted Cell Fate

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