
Songbai Liu
Suzhou Vocational Health College, Jiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology, Suzhou Key Laboratory of Medical Biotechnology
Prof. Dr. Songbai Liu is head of Suzhou Key Laboratory of Medical Biotechnology and one of the research direction Leaders in Jiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology. His main research interests are mechanistic studies on tumorigenesis and drug resistance, DNA damage events as biomarkers for disease diagnosis and prognosis, and targeted inhibitor screening.He is also the Jiangsu Province “Qinglan Program” Academic Leader, Jiangsu Province “333 Program” High-Level Talent, and Jiangsu Province Youth High-level Medical Talent. He is a member of the Editorial Board of the Journal of Molecular and Clinical Oncology, BIOCELL, Medicine International and a guest reviewer editor of Frontiers in Oncology. He has published more than 60 academic papers and received 21 granted patents.

Min Li
Hunan Provincial Maternal and Child Health Care Hospital, University of South China; National Health Commission Key Laboratory of Birth Defect Research and Prevention, Institute of Biochemistry and Molecular Biology, Hengyang Medical school
Prof. Dr. Min Li is a professor at Institute of Biochemistry and Molecular Biology, Hengyang Medical school, University of South China. Her main research aims to understand how defects in DNA synthesis and repair contribute to cancer pathogenesis and aging. Specially, the main project of her laboratory focus on transcription-replication conflict associated with genome instability. Dr. Min Li is also a core member of National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha.

Haitao Sun
Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Medicinal Plant Development
Prof. Dr. Haitao Sun is a Principal Investigator of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College. Her main research interests are mechanistic studies on DNA replication and DNA damage response, sister chromatid cohesion, tumorigenesis, tumor drug resistance and anti-cancer activities of medicinal plants. She is also on the list of National of High-Level of Talent Program. She is a member of Chinese Society for Cell Biology. She has published more than 10 academic papers in top journals, such as Science, Acta Pharmaceutica Sinica B, Trends Cell Biology, and received 3 patents.

Di Xin
Zhejiang University School of Medicine, the First Affiliated Hospital, MOE Joint International Research Laboratory of Pancreatic Diseases, Zhejiang Provincial Key Laboratory of Pancreatic Disease, Department of Hepatobiliary and Pancreatic Surgery
Prof. Dr. Di Xin is a Principal Investigator of Zhejiang Provincial Key Laboratory of Pancreatic Disease and MOE Joint International Research Laboratory of Pancreatic Diseases at the First Affiliated Hospital of Zhejiang University School of Medicine. His main research interests are studies on the molecular mechanism of DNA damage repair and tumor development, and the role and molecular mechanism of molecules that maintain genomic stability in innate immunity. Dr. Di Xin is a core member of Hangzhou Leading Innovation and Entrepreneurship Team, a member of Chinese Association of Pancreatology, and a member of Chinese Society for Cell Biology, and a member of is DDRHD (the international symposium on DNA Damage Response & Human Disease) of the Chinese Society of Biochemistry and Molecular Biology.
Cells respond to genotoxic stress through complex protein pathways known as the DNA damage response (DDR). This DDR system ensures genome stability by recognizing DNA damage, recruiting response-related proteins, performing cleavage and gap filling, and causing DNA damage-related cell cycle arrest and cell death. These response events significantly impact various human diseases, notably cancer, neurodegenerative disorders, immune deficiencies, and aging.
The Methods Collection aims to provide a comprehensive resource for the research community, offering detailed methods and protocols related to studying the DNA damage response. Some examples of methods included in this collection are as follows:
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2025
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Rongcheng Li*1, Shui Yang*2, Yu Sha*2,3, Xiao Liu1, Jiani Ge1, Dandan Tang1, Rui Liang2, Song-Bai Liu1,2,3
1School of Chemistry and Life Sciences, Suzhou University of Science and Technology, 2Jiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology, Suzhou Vocational Health College, 3Jiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College
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2025
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Jiani Ge*1,2, Yunfan Sun*3, Jingsheng Hua*4, Yuanhong Huang5, Yi Wang2, Dandan Tang1, Taoyun Wang1, Jinli Li6, Yanfeng Deng7, Song-Bai Liu1,2
1Department of Chemistry and Life Sciences, Suzhou University of Science and Technology, 2Jiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology, Suzhou Vocational Health College, 3Department of Hematology, The Second Affiliated Hospital of Soochow University, 4Taizhou University Affiliated Municipal Hospital, School of Medicine, Taizhou University, 5National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, 6Department of Radiation Oncology, The Affiliated Hospital of Soochow University, 7Department of Medical Ultrasound, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine
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2025
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Feng Zhang1, Hao Zhang1, Jinjing Xu1, Ruipeng Wang1, Hanqin Xuan2, Shenghua Zhan2, Lei Cao3,4,5, Ling Gao1
1Department of General Surgery, The First Affiliated Hospital of Soochow University, 2Department of Pathology, The First Affiliated Hospital of Soochow University, 3Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 4Jiangsu Key Laboratory of Clinical Immunology, Soochow University, 5Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology, The First Affiliated Hospital of Soochow University
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2026
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Fang-Tong Liu*1,2, Yuan-Hong Huang*1,2, Shuai-Shuai Ge1,2, Chao-Ling Wan1,2, Miao Wang1,2, Zhi-Zhi Zhang1,2, Yan-Yan Li1,2, Hai-Hui Liu1,2, Hong-Feng Pang1,2, Xiao-Yu Lyu1,2, Zheng Li1,2, Hai-Ping Dai1,2, Song-Bai Liu3, Sheng-Li Xue1,2
1National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, 2Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, 3Jiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College
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1Jiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College, 2School of Chemistry and Life Sciences, Suzhou University of Science and Technology, 3Department of Orthopedics, The First Affiliated Hospital of Soochow University, 4Department of Hematology, The First Affiliated Hospital of Soochow University
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1School of Life Sciences, North China University of Science and Technology, 2Jiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology, Suzhou Vocational Health College, 3Thyroid and Breast Surgery, Wuzhong People's Hospital of Suzhou City, 4School of Chemistry and Life Sciences, Suzhou University of Science and Technology
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2026
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Yijie Wu*1,2, Zhen Jin*3, Jiahui Du*2, Ling Li3, Wang Ouyang2, Lei Yin4, Shuai Zhao4, Jinli Li5, Xiaohua Li4, Song-Bai Liu1,2,3
1College of Life Science, North China University of Science and Technology, 2Jiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College, 3School of Chemistry and Life Sciences, Suzhou University of Science and Technology, 4Thyroid and Breast Surgery, Wuzhong People's Hospital of Suzhou City, 5Department of Radiation Oncology, The Affiliated Hospital of Soochow University
Autophagy-Related Signature Identifies ALDH1A3 as a Biomarker for Immunity and Progression in Gastric Cancer
Ruipeng Wang1,
Jinjing Xu1,
Hao Zhang1,
Qiang Huo1,
Qiange Zhang2,
Yunwen Tao*3,
Ling Gao*1
1Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, China,
2Jiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China,
3Department of Clinical Nutrition, Second Affiliated Hospital of Soochow University, Suzhou, China
Live cell imaging of bacterial DNA for assessing DNA damage potential of antibiotics, and pesticides
Sutharsan Govindarajan*1
1Department of Biological Sciences, School of Engineering and Sciences (SEAS), SRM University-AP
EIF4EBP1 in Breast Cancer: Translational Control, Regulatory Networks, and Therapeutic Frontiers
Weijia Liu1,
Lili Hou2,
Dandan Tang3,
Haiyu Mou4,
Weijie Wang5,
Song-Bai Liu*6,
Xiaohua Li*2
1College of Life Science, North China University of Science and Technology, Bohai Avenue 21,Tangshan 063210, China; Jiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology, Suzhou Vocational Health College, Kehua Road 28, Suzhou 215009, China,
2Thyroid and breast surgery, Wuzhong people’s Hospital of Suzhou City, Suzhou 215128, China,
3School of Chemistry and Life Science, Biology and Materials Engineering, Suzhou University of Science and Technology, Suzhou 215009, China,
4Jiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology, Suzhou Vocational Health College, Kehua Road 28, Suzhou 215009, China,
5College of Life Science, North China University of Science and Technology, Bohai Avenue 21,Tangshan 063210, China,
6College of Life Science, North China University of Science and Technology, Bohai Avenue 21,Tangshan 063210, China; Jiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology, Suzhou Vocational Health College, Kehua Road 28, Suzhou 215009, China; School of Chemistry and Life Science, Biology and Materials Engineering, Suzhou University of Science and Technology, Suzhou 215009, China
DNA Damage Repair Systems in 5-Fluorouracil Resistance of Colorectal Cancer: Mechanistic Insights and Therapeutic Intervention Strategies
Dandan Tang1,
Yi Yu2,
Ping Xu3,
Xiaoxiao Wang4,
Song-Bai Liu*4
1School of Chemistry and Life Science, Suzhou University of Science and Technology, Suzhou, China,
2Department of Traditional Chinese Medicine Anorectal Surgery, The Second People's Hospital of Kunshan City, Suzhou, China ,
3Department of Clinical Laboratory, The Fifth People’s Hospital of Suzhou, The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, China,
4Jiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College, Suzhou, China