Automated Screening Platform

An automated screening platform is an integrated system that uses robotics, instrumentation, and software to test biological samples or experimental conditions systematically and efficiently. It typically performs standardized liquid handling, sample preparation, assay execution, and data collection, while computational analysis compares measurements to identify responses, phenotypes, or promising candidates. In biology, these platforms support high-throughput screening of genes, compounds, cells, and molecular interactions, reducing manual variability and enabling researchers to evaluate large experimental libraries. Their reproducibility and scalability can accelerate studies of cellular function, disease mechanisms, drug discovery, and therapeutic development.

Automated Screening Platform - Related Videos

Research

JoVE Journal - Biology
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Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis

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Cited by 18 •

2016

We present an automated modular high-throughput-method for the identification and characterization of microbial exopolysaccharides in small scale. This method combines a fast preselection to analyze the total amount of secreted polysaccharides with a detailed carbohydrate fingerprint to enable the fast screening of newly isolated bacterial strains or entire strain collections.

Research

JoVE Journal - Biology
Free Sample

Development of automated imaging and analysis for zebrafish chemical screens.

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Cited by 48 •

2010

We report the development of a system for automated imaging and analysis of zebrafish transgenic embryos in multiwell plates. This demonstrates the ability to measure dose dependent effects of a small molecule, BCI, on Fibroblast Growth Factor reporter gene expression and provide technology for establishing high-throughput zebrafish chemical screens.

GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization

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Cited by 8 •

2011

GENPLAT (GLBRC Enzyme Platform) is an automated platform for discovery and optimization of enzyme cocktails for biomass degradation. It can be adapted to multiple feedstocks and mixtures of enzymes containing multiple components.

Research

JoVE Journal - Bioengineering

A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments

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Cited by 3 •

2013

We have developed an automated cell culture and interrogation platform for micro-scale cell stimulation experiments. The platform offers simple, versatile, and precise control in cultivating and stimulating small populations of cells, and recovering lysates for molecular analyses. The platform is well suited to studies that use precious cells and/or reagents.

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells

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Cited by 6 •

2013

Achieving a systems level understanding of cellular processes is a goal of modern-day cell biology. We describe here strategies for multiplexing luciferase reporters of various cellular function end-points to interrogate gene function using genome-scale RNAi libraries.

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