Colonic Flexures

Colonic flexures are the sharp bends that connect the major sections of the large intestine, helping the colon fit within the abdominal cavity while maintaining the pathway for intestinal contents. The hepatic flexure turns the ascending colon into the transverse colon near the liver, whereas the splenic flexure turns the transverse colon into the descending colon near the spleen; their positions are supported by surrounding peritoneal and connective-tissue attachments. These anatomical landmarks guide the movement of fecal material and help clinicians describe abdominal regions, interpret imaging, and locate abnormalities such as obstruction, inflammation, or tumors during diagnostic and surgical procedures.

Colonic Flexures - Related Videos

Research

JoVE Journal - Bioengineering

Flexural Rigidity Measurements of Biopolymers Using Gliding Assays

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Cited by 2 •

2012

A method to measure the persistence length or flexural rigidity of biopolymers is described. The method uses a kinesin-driven microtubule gliding assay to experimentally determine the persistence length of individual microtubules and is adaptable to actin-based gliding assays.

Education

JoVE Core - Mechanical Engineering

Flexural Stress

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2024

When analyzing bending in symmetric members, it's crucial to understand how stresses distribute when subjected to bending moments. This stress distribution is effectively described by applying fundamental mechanics and material science principles, particularly Hooke's Law for elastic materials. Hooke's Law states that within the material's elastic limits, stress is directly proportional to strain. In a member experiencing a bending moment, the strain at any point is relative to its distance...

Electrophysiological Recording from Colonic Afferent Nerves in an Ex Vivo Rat Colon

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2025

This video demonstrates a method to record the activity of colonic afferent nerves in an ex-vivo rat colon, cannulated at both ends and infused with saline to increase intraluminal pressure. As pressure increases, the nerve signal rises, indicating its stimulation.

A Murine Model of Group B Streptococcus Vaginal Colonization

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Cited by 64 •

2016

The purpose of this protocol is to imitate human group B Streptococcus (GBS) vaginal colonization in a murine model. This method may be used to investigate host immune responses and bacterial factors contributing to GBS vaginal persistence, as well as to test therapeutic strategies.

Quantification of Colonic Stem Cell Mutations

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Cited by 1 •

2015

We report significant improvements for the reproducible measurement of somatic colonic stem cell mutations after exposure of mice to potential DNA damaging agents.

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