Hepatic Circulation
Hepatic Circulation - Related Videos
10:40
Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
0 Views •
Cited by 10 •
2012
An optical system was developed to visualize hepatic microcirculation with FITC-labeled erythrocytes and to measure the partial pressure of oxygen in the microvessels with laser-assisted phosphorimetry. This method can be used to investigate physiological and pathological mechanisms by analyzing microvascular structure, diameter, blood flow velocity, and oxygen tension.
06:53
Selective Harvesting of Marginating-hepatic Leukocytes
0 Views •
Cited by 1 •
2016
Marginating-hepatic leukocytes exhibit unique characteristics and distinct immunological functions compared to other leukocyte populations. Here we describe a method for selective harvesting of this specific hepatic cell population, through forced perfusion of the liver of rats or mice. Marginating-hepatic leukocytes seem critical in determining susceptibility to hepatic-related diseases and metastases.
09:35
Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
0 Views •
Cited by 2 •
2017
Here we describe a newly developed hepatitis B virus (HBV) reporter system to monitor the early stages of the HBV life cycle. This simplified in vitro system will aid in the screening of anti-HBV agents using a high-throughput strategy.
09:02
Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
0 Views •
Cited by 12 •
2016
In this manuscript, we describe percutaneous isolated hepatic perfusion with simultaneous chemofiltration as treatment for unresectable liver metastases. This procedure is performed under general anaesthesia in the angiosuite by an experienced team, consisting of an interventional radiologist, a clinical perfusionist and anaesthesiologist.
05:23
Murine Bioluminescent Hepatic Tumour Model
0 Views •
Cited by 11 •
2010
This article describes a procedure for the induction of orthotopic bioluminescent liver tumours in mice, and subsequent analysis of tumour growth confined to the liver using live whole body luminescence imaging.
FAQs
The two inflows provide complementary resources rather than duplicating one another. The hepatic artery contributes oxygen-rich blood, whereas the hepatic portal vein delivers absorbed, nutrient-rich blood from digestive organs. Bringing these streams together allows liver cells to receive oxygen while directly encountering substances that require modification, storage, detoxification, or other metabolic processing.
Mixing in the hepatic sinusoids exposes hepatocytes to both oxygenated blood and substances arriving from digestion. This arrangement places absorbed materials in the correct cellular environment for processing before the blood leaves the liver. As a result, the liver can alter or store nutrients and help clear drugs and metabolic wastes from the circulating blood.
Its organization connects digestive absorption with broader metabolic control. After substances enter the liver, hepatocytes can modify or store nutrients, support glucose regulation, produce plasma proteins, form bile, and clear drugs or metabolic wastes. These activities help stabilize internal conditions while coordinating the liver’s functions with nutrient delivery from the digestive organs.
This drainage route collects blood after it has passed through liver sinusoids and encountered hepatocytes. Central veins therefore represent the transition from local processing to hepatic outflow, while hepatic veins carry the processed blood away from the liver. Following this direction helps distinguish incoming delivery from the blood’s exit after hepatic modification.
Begin with the hepatic artery and hepatic portal vein as separate incoming vessels. Follow both streams into the hepatic sinusoids, where they mix and pass by hepatocytes. Then trace the blood into central veins and onward through the hepatic veins. This sequence clarifies how delivery, cellular processing, and drainage form one connected pathway.
The system provides a framework for examining how the liver handles substances absorbed from the digestive organs and how that handling affects the rest of the body. Relevant processes include glucose regulation, nutrient storage or modification, plasma protein production, bile formation, and clearance of drugs and metabolic wastes. Together, these functions link organ-level circulation to whole-body physiology.