Biocompatible Glue Application
Biocompatible Glue Application - Related Videos
08:40
TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
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Cited by 12 •
2016
We describe the simplest protocol to prepare biodegradable medical glue that has an effective hemostatic ability. TAPE is a water-immiscible supramolecular aggregate prepared by mixing of tannic acid, a ubiquitous compound found in plants, and poly(ethylene) glycol, yielding a 2.5 times greater water-resistant adhesion compared with commercial fibrin glue.
03:47
Implantation of a Flexible Biocompatible Probe in a Glioblastoma Mouse Model
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2025
Source: Lefevre, M. C., et al., Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma. J. Vis. Exp. (2022)This video demonstrates the implantation of a flexible, biocompatible probe in a glioblastoma mouse model to deliver targeted pulsed electric field therapy for neurotherapeutic applications.
06:15
A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
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Cited by 8 •
2015
This protocol aims to alleviate the limitation of poor cell engraftment for stem cell treatment of myocardial infarctions through the use of a hydrogel system and a fibrin-based glue. With this approach, cell-to-tissue contact post-infarction can be maintained, increasing the therapeutic potential of beneficial agents at the site of injury.
13:38
Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
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Cited by 9 •
2017
This study presents a methodology to prepare 3D, biodegradable, foam-like cell scaffolds based on biocompatible side-chain liquid crystal elastomers (LCEs). Confocal microscopy experiments show that foam-like LCEs allow for cell attachment, proliferation, and the spontaneous alignment of C2C12s myoblasts.
08:09
Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
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Cited by 1 •
2019
This work presents the preparation of methionine functionalized biocompatible block copolymers (mBG) via the reversible addition-fragmentation chain transfer (RAFT) method. The plasmid DNA complexing ability of the obtained mBG and their transfection efficiency were also investigated. The RAFT method is very beneficial for polymerizing monomers containing special functional groups.
FAQs
Polymerization and crosslinking create a connected adhesive structure that can hold biological surfaces together after application. Their role is especially important when the glue must maintain contact under physiological conditions rather than simply adhere briefly. The resulting network contributes to attachment, sealing, or stabilization, while its compatibility with nearby cells and tissues remains essential for a useful outcome.
Biological fluids can interfere with contact between an adhesive and the surface, making reliable attachment more challenging than adhesion to a dry material. A suitable formulation must therefore function in the presence of those fluids while preserving its barrier or stabilizing role. This property matters in settings where damaged tissue remains exposed to physiological conditions during and after application.
Four linked properties are central: adhesion strength, biocompatibility, degradation, and performance in biological fluids. Strong adhesion supports closure or stabilization, whereas biocompatibility limits harmful effects on surrounding cells and tissues. Degradation influences how the adhesive persists, and fluid tolerance determines whether it can continue functioning after placement. Evaluating these properties together helps match the glue to the intended biological use.
The adhesive can be applied to damaged surfaces to maintain contact and form a localized barrier. In immunology and infection research, this supports wound closure and sealing of compromised barriers, which are relevant when tissue integrity affects exposure to the surrounding environment. The outcome depends on whether the glue remains attached under physiological conditions without producing harmful effects in adjacent tissues.
Localized delivery is an application when the adhesive has been specifically designed to carry antimicrobial or immune-modulating materials. The glue then serves not only as a physical seal or stabilizer but also as a means of retaining those materials at the selected biological site. This use connects adhesive design with infection research and immune-response studies while requiring attention to tissue compatibility.
Researchers should examine whether the treated surfaces remain attached, sealed, or stabilized under physiological conditions and whether surrounding cells and tissues tolerate the material. They should also consider how the adhesive degrades and whether biological fluids compromise its function. In infection or immunology studies, additional outcomes may include the effectiveness of localized antimicrobial or immune-modulating delivery when that feature is part of the design.