Ligament Re-rupture

Ligament re-rupture is the repeated tearing of a ligament after an initial injury, surgical repair, or reconstruction, and it can compromise joint stability and recovery. It occurs when healing tissue or a graft cannot withstand mechanical loading, often during reinjury before biological integration and functional strength are restored; altered movement and persistent instability can further increase stress on the ligament. In medicine, recognizing re-rupture supports clinical assessment through history, physical examination, and imaging, while informing decisions about activity modification, rehabilitation, or revision surgery. Studying its causes and outcomes helps improve surgical techniques, graft selection, rehabilitation timing, and prevention of recurrent joint dysfunction.

Ligament Re-rupture - Related Videos

Research

JoVE Journal - Immunology and Infection
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Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens

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Cited by 22 •

2013

We describe a method for tracking the endomembrane rupture elicited by the intracellular bacteria Shigella flexneri and Mycobacterium tuberculosis upon host cell invasion. Our assay makes use of CCF4, a host cytoplasmic FRET probe in live or fixed cells. This reporter is degraded by an enzyme activity present on the bacterial surface.

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model

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Cited by 7 •

2017

We present a model of ligament tissue in which three-dimensional constructs are treated with the human exercise-conditioned serum and analyzed for collagen content, function, and cellular biochemistry.

Research

JoVE Journal - Immunology and Infection

A Photodynamic Approach to Study Function of Intracellular Vesicle Rupture

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2023

AlPcS2a-mediated chromophore-assisted laser inactivation (CALI) is a powerful tool for studying spatiotemporal damage of intracellular vesicles (IVs) in live cells.

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

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Cited by 9 •

2018

We report methods for characterization of MLKL-mediated plasma membrane rupture in necroptosis including conventional and confocal live-cell microscopy imaging, scanning electron microscopy, and NMR-based lipid binding.

Research

JoVE Journal - Engineering
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Predicting Catalyst Extrudate Breakage Based on the Modulus of Rupture

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Cited by 3 •

2018

Here we present a protocol to measure the modulus of rupture of an extruded catalyst and the breakage of said catalyst extrudates by collision against a surface or by compression in a fixed bed.

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