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Mouse Kidney Transplantation: Models of Allograft Rejection
JoVE Journal
Medicine
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JoVE Journal Medicine
Mouse Kidney Transplantation: Models of Allograft Rejection
DOI:

16:15 min

October 11, 2014

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Chapters

  • 00:00Title
  • 00:48Surgical Preparation
  • 02:05Donor Procedure – Kidney Preparation
  • 04:27Donor Procedure – Kidney Harvest
  • 05:25Recipient Procedure – Preparation
  • 07:15Recipient Procedure – Transplant
  • 11:48Post-operative Care
  • 12:35Representative Results: Renal Structure
  • 15:37Conclusion

Summary

Automatic Translation

Here, we present a protocol to study the immunology of rejection. The surgical model presented reports a short operating time and a concise technique. Depending on the donor-recipient strain combination, the transplanted kidney may develop acute cellular rejection or chronic allograft damage, defined by interstitial fibrosis and tubular atrophy.

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