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Biochemistry

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JoVE Journal Biochemistry
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
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A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

Article DOI: 10.3791/59773-v • 07:32 min • August 30th, 2019
August 30th, 2019 •
1,2, 1,2, 3, 1,2
1Nebraska Center for Virology, 2School of Biological Sciences, University of Nebraska-Lincoln, 3Department of Food Science and Technology, University of Nebraska-Lincoln

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Summary
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We describe a novel method for generating double humanized BLT-mice that feature a functional human immune system and a stable engrafted human-like gut microbiome. This protocol can be followed without the need for germ-free mice or gnotobiotic facilities.

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Double Humanized BLT-mice Model Human Gut Microbiome Human Immune System Translational Biomedical Research In Vivo Relationships Liver And Thymus Tissues Sublethal Irradiation Sedation Iodine And Isopropanol Scrubs Human Fetal Liver Tissue Human Fetal Thymus Tissue
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