Immunology and Infection
A subscription to JoVE is required to view this content.
You will only be able to see the first 2 minutes.
Summary December 18th, 2012
The generation and characterization of tumor specific T cells using humanized mice is described here. Human thymic tissue and genetically modified human hematopoietic stem cells are transplanted into immunocompromised mice. This results in the reconstitution of an engineered human immune system allowing for in vivo examination of anti-tumor immune responses.