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JoVE Journal
Biology

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A Highly Reproducible and Straightforward Method to Perform In Vivo Ocular Enucleation in the Mouse after Eye Opening
 

A Highly Reproducible and Straightforward Method to Perform In Vivo Ocular Enucleation in the Mouse after Eye Opening

Article DOI: 10.3791/51936-v 05:29 min October 6th, 2014
October 6th, 2014

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Summary

The removal of eyes, also called enucleation, provides a useful strategy to study aspects of visual, cross-modal, and developmental plasticity along the mammalian visual system since it induces irreversible partial (monocular) or complete (binocular) vision loss. Here we describe a highly reproducible and straightforward approach to perform in vivo enucleation.

Tags

Ocular Enucleation Mouse Model Nerve Deafferentation Visual System Plasticity Surgical Technique Optic Nerve Eyeball Removal Reproducibility Minimal Bleeding Post-operative Recovery Low Learning Threshold Retina Damage Post-eye Opening Ages
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