Migraine Mouse Model
Migraine Mouse Model - Related Videos
16:13
Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
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Cited by 18 •
2011
Migraine and its transformation to chronic migraine are immense healthcare burdens in need of improved treatment options. We seek to define how neural immune signaling modulates the susceptibility to migraine, modeled in vitro using spreading depression in hippocampal slice cultures, as a means to develop novel therapeutic targets.
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Cited by 14 •
2014
In this study, the authors report for the first time a novel 3D-Immersive & Interactive Neuronavigation (3D-IIN) through the impact of a spontaneous migraine headache attack in the μ-opioid system of a patient's brain in vivo.
05:23
Investigating Migraine-Like Behavior Using Light Aversion in Mice
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Cited by 19 •
2021
Rodents are not able to report migraine symptoms. Here, we describe a manageable test paradigm (light/dark and open field assays) to measure light aversion, one of the most common and bothersome symptoms in patients with migraines.
06:24
Mouse Models of Periventricular Leukomalacia
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Cited by 28 •
2010
We established mouse models of periventricular leukomalacia (PVL), the predominant brain injury in premature infants characterized by periventricular white matter lesions. Hypoxia/ischemia with/without systemic infection are the primary causes of PVL. Unilateral carotid ligation and hypoxia exposure with/without lipopolysaccharide injection creates PVL-like lesions in P6 mice.
07:37
Mouse Models for Graft Arteriosclerosis
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Cited by 17 •
2013
We describe protocols for our mouse graft arteriosclerois (GA) models which involve interposition of a mouse vessel segment into a recipient of the same inbred strain. By backcrossing additional genetic changes into the vessel donor, the model can assess the effect of specific genes on GA.
FAQs
Nitroglycerin-based models stimulate nitric oxide signaling, whereas cortical spreading depression activates pathways that connect brain activity with the trigeminal pain system. These approaches therefore provide complementary experimental routes for examining migraine-related mechanisms. Comparing behavioral responses across the two paradigms can help researchers determine which observable features are shared and which depend on the initiating biological pathway.
No single behavior captures every migraine-related feature. Periorbital mechanical allodynia examines sensitivity around the eye, while light aversion reflects responses to environmental illumination. Changes in spontaneous activity add information about general behavioral state. Considering these measures together allows investigators to connect pain-related sensitivity, sensory responses, and activity changes without relying on one outcome alone.
Light aversion provides a behavioral readout of how environmental visual stimulation affects mice after migraine-related pathways are activated. When interpreted alongside periorbital mechanical allodynia and spontaneous activity, it helps distinguish sensory responses from changes in pain sensitivity or overall behavior. This makes environmental stimuli an important part of studying how migraine biology produces observable symptoms.
Researchers first select an induction approach, such as nitroglycerin administration or cortical spreading depression, to activate the relevant migraine-related pathway. They then examine outcomes through measures such as periorbital mechanical allodynia, light aversion, and spontaneous activity. Comparing these behavioral results with the selected induction method helps relate pathway activation to specific observable responses.
Behavioral testing can reveal changes in sensitivity around the periorbital region, aversion to light, and spontaneous activity. Together, these outcomes provide observable evidence of altered pain processing, sensory responsiveness, and behavior after migraine-related pathway activation. The resulting profile can be used to connect neural mechanisms with symptom-like features and to compare responses across experimental conditions.
Researchers can use these models after establishing migraine-related behavioral responses to test whether an intervention changes periorbital mechanical allodynia, light aversion, or spontaneous activity. Improvement in one or more measures may indicate an effect on specific symptom-related processes. Using several outcomes also helps determine whether a treatment influences pain sensitivity, sensory responses, general activity, or more than one domain.