Stroke Diagnosis
Stroke Diagnosis - Related Videos
07:34
FISH for Pre-implantation Genetic Diagnosis
0 Views •
Cited by 17 •
2011
This article describes the selection of suitable probes for single-cell FISH, spreading techniques for blastomere nuclei, and in situ hybridization and signal scoring, applied to pre-implantation genetic diagnosis (PGD) in a clinical setting.
08:14
Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
0 Views •
Cited by 103 •
2014
Various murine models of middle cerebral artery occlusion (MCAO) are widely used in experimental brain research. Here, we demonstrate the model of transcranial permanent distal MCAO which produces consistent cortical infarction of a size corresponding to damage imposed by the majority of human ischemic strokes.
06:38
The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
0 Views •
2025
To simulate thromboembolic stroke, emboli prepared from heterologous rat blood were injected into the middle cerebral artery, followed by administration of systemic thrombolysis for recanalization. This version of the model is optimized for use in a multi-laboratory network and supports testing multiple candidate therapeutics.
10:45
The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
0 Views •
2025
This article presents a protocol for executing the highly translational and independently proven mouse Stroke Unit (mSU) concept in large-stroke mice. It also provides a standardized protocol for executing the focal experimental stroke scale in mice, which evaluates stroke focal deficits detected even long-term.
02:59
Stereotactic Injection of Hydrogel into a Post-Stroke Mouse Model
0 Views •
2025
Source: Wilson, K.L., et al. Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke. J. Vis. Exp. (2020)This video demonstrates the stereotaxic injection of a hydrogel into the stroke core of a post-stroke mouse, highlighting its role in scaffold formation that mimics the extracellular matrix, promotes cellular infiltration, and supports angiogenesis, underscoring its neurotherapeutic potential in stroke recovery.
FAQs
Noncontrast computed tomography is used to identify brain bleeding, while magnetic resonance imaging can reveal early ischemic injury and vascular imaging can show a vessel occlusion. These modalities answer different diagnostic questions rather than serving as interchangeable tests. Their complementary findings help clinicians classify the event and select urgent treatment pathways based on the underlying pathology.
Timing and neurological examination add information that images alone may not provide. Recording when symptoms began helps place the event within a time-sensitive clinical course, while examination identifies affected functions and helps relate deficits to neural systems. Together, these observations support interpretation of imaging, assessment of likely brain involvement, and urgent decisions about care.
Stroke diagnosis must also account for conditions that mimic stroke symptoms. The clinical picture and imaging are evaluated together so that a sudden neurological disturbance is not attributed to the wrong cause. Distinguishing a true stroke from a mimic, and separating ischemia from hemorrhage when stroke is present, is important because the diagnosis determines the appropriate urgent treatment direction.
An acute evaluation begins with symptom-onset information and a neurological examination, followed by brain imaging selected to clarify the suspected pathology. Noncontrast CT assesses for hemorrhage; MRI can demonstrate early ischemic injury, and vascular imaging evaluates vessel occlusion. The combined results establish the diagnosis, characterize affected brain systems, and support time-sensitive treatment decisions.
MRI is particularly informative when clinicians need to identify early ischemic injury, whereas vascular imaging is valuable for showing whether a vessel is occluded. Noncontrast CT addresses a different immediate question by detecting hemorrhage. Using the modality that matches the diagnostic uncertainty improves characterization of the event and can inform urgent reperfusion decisions.
Beyond acute treatment, diagnostic findings connect clinical deficits with brain organization. Identifying affected neural systems helps explain which functions have been disrupted, while distinguishing ischemic injury from hemorrhage provides a framework for interpreting underlying brain damage. In neuroscience research, this information supports study of brain injury and recovery, as well as prognosis.