Assessing Serum Neutralization Against SARS-CoV-2 with Pseudotyped Viruses

November 21, 2023

假型病毒作为通过中和测定监测针对 SARS-CoV-2 的体液免疫反应的分子工具

SARS-CoV-2 假型病毒生产和血清中和试验

Tobia Fantoni*¹, Michele Bissoli*¹, Chiara Stefani, Mauro Voi, Alexandrina Dabija, Rebecca Casula, Domenico Luca Minafra, Julys da Fonseca Palmeira, Enrique Roberto Argañaraz, Martin Mayora-Neto, Nigel J. Temperton, Donato Zipeto, Alessandra Ruggiero

¹Department of Neuroscience, Biomedicine and Movement,University of Verona, ²Laboratory of Molecular Neurovirology, Faculty of Health Science,University of Brasília, ³Viral Pseudotype Unit, Medway School of Pharmacy,Universities of Kent and Greenwich at Medway

Summary

假型病毒（PV）是复制缺陷的病毒粒子，用于在比处理真实病毒更安全的条件下研究宿主-病毒相互作用。这里介绍的是一个详细的方案，显示了如何使用 SARS-CoV-2 PV 来测试 COVID-19 疫苗接种后患者血清的中和能力。

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