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Cancer Research

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JoVE Journal Cancer Research

Lentiviral Infection of MPNST Cells and Genomic DNA Isolation for Genome-Scale shRNA Screens (Video) | JoVE

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Journal (Cancer Research)

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Establishment and Analysis of Three-Dimensional (3D) Organoids Derived from Patient Prostate Cancer Bone Metastasis Specimens and their Xenografts

Journal (Cancer Research)

Establishment and Analysis of Three-Dimensional (3D) Organoids Derived from Patient Prostate Cancer Bone Metastasis Specimens and their Xenografts

Lentiviral Infection of MPNST Cells and Genomic DNA Isolation for Genome-Scale shRNA Screens (Video) | JoVE

Genome-Scale Screening to Identify and Compare Therapeutic Targets in Tumors

Article DOI: 10.3791/200478-v • 03:50 min • August 25th, 2023

August 25th, 2023 •

Brittany Turner-Ivey¹, Jody Fromm Longo², Dorea P. Jenkins², Stephen T. Guest³, Steven L. Carroll^1,2

¹Hollings Cancer Center, Medical University of South Carolina, ²Department of Pathology and Laboratory Medicine, Medical University of South Carolina, ³Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor

Tags

Genetic Profiling Genome-scale Dropout Screening Therapeutic Targets Mouse Models Malignant Peripheral Nerve Sheath Tumor Schwann Cells Neurofibromatosis Type 1 (NF1) Soft-tissue Sarcoma Disease-free Survival Rates Treatment Options Disfiguring Surgery Tipifarnib Ras Signaling Inhibitor Erlotinib Epidermal Growth Factor (EGFR) Inhibitor Sorafenib Vascular Endothelial Growth Factor Receptor (VEGF) Inhibitor Platelet-derived Growth Factor Receptor (PDGF) Inhibitor Raf Inhibitor Functional Genomic Screening Cancer Cell Lines Cytoplasmic Signaling Pathways Target-specific Therapies

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