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Journal / Immunology and Infection / Inductie van allogeen-specifieke anergie in…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Inductie van allogeen-specifieke anergie in humane perifere bloed mononucleaire cellen door allogeen stimulatie met Co-stimulerende signaal blokkade
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Inductie van allogeen-specifieke anergie in humane perifere bloed mononucleaire cellen door allogeen stimulatie met Co-stimulerende signaal blokkade

Article DOI: 10.3791/2673-v • 11:55 min • March 14th, 2011
March 14th, 2011 •
1,2, 1, 1, 1,2, 3,4
1Medical Oncology, Dana Farber Cancer Institute, 2Department of Medicine, Brigham and Womens Hospital, 3Pediatric Oncology, Dana Farber Cancer Institute, 4Division of Hematology/Oncology, Children’s Hospital Boston

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Dit artikel beschrijft een eenvoudige techniek om allogeen-specifieke anergie induceren in humane perifere bloed mononucleaire cellen. De techniek kan klinisch worden toegepast op niet-alloreactieve donorcellen te genereren. Infusie van deze cellen zou kunnen verbeteren immuun reconstitutie en vermindering van toxiciteit na allogene hematopoietische stamceltransplantatie.

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Immunologie allogene stamceltransplantatie alloreactiviteit Graft-versus-Host ziekte T-cel costimulatie anergie gemengde lymfocyt reactie.
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