需要订阅 JoVE 才能查看此. 登录或开始免费试用。
Chapters
- 00:05Title
- 00:41Synthesis of Carbamate from Di-Boc Agmatine Isocyanate and 2,4-DibromoHGAL
- 03:12Purification of Carbamate
- 05:53Synthesis and Isolation of Clavatadine A
- 07:25Results: Synthesis and Characterization of Clavatadine A and Its Precursors
- 08:19Conclusion
Here, we present a protocol for direct, early stage guanidinylation that enables rapid total synthesis of aminoguanidine-containing small organic molecules. An advanced synthetic intermediate used in the synthesis of a blood coagulation factor XIa inhibitor was prepared using this protocol.
