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Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury

Article DOI: 10.3791/54700-v • 09:16 min • February 26th, 2017
February 26th, 2017 •
1,2, 3, 1,2, 1,2, 1,2
1Department of Anesthesiology, University at Buffalo, State University of New York, 2Department of Anesthsiology, Veterans Admistration Western New York Healthcare System, 3Institute of Lasers, Photonics and Biophotonics, University at Buffalo, State University of New York

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This protocol induces acute lung injury in a mouse that has close fidelity to the pathogenesis of acid pneumonitis observed in humans. We generate a maximal acute nonlethal low pH lung injury and account for differences in rodent-human anatomic respiratory structure using an open tracheostomy coupled with circumferential pressure release.

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Open Tracheostomy Gastric Acid Aspiration Murine Model Acute Lung Injury Acid Pneumonitis Sterile Acute Lung Injury Therapeutic Strategies Genetically Engineered Animals Anesthesia Surgical Area Disinfection Braided Silk Suture Supine Position Nose Cone Isoflurane Anesthesia Povidone Iodine
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