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JoVE Journal Neuroscience
Targeting Alpha Synuclein Aggregates in Kutane periphere Nervenfasern durch frei schwebenden Immunfluoreszenz-Assay
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Targeting Alpha Synuclein Aggregates in Kutane periphere Nervenfasern durch frei schwebenden Immunfluoreszenz-Assay

Article DOI: 10.3791/59558-v • 08:33 min • June 25th, 2019
June 25th, 2019 •
1, 1, 1,2,3,4, 1,2
1Laboratory for Biomedical Neurosciences, Neurocenter of Southern Switzerland, 2Neurology Department, Neurocenter of Southern Switzerland, 3Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 4Faculty of Biomedical Sciences, Università della Svizzera Italiana

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Hier stellen wir ein Protokoll für einen frei schwebenden indirekten Immunfluoreszenz-Assay auf Hautbiopsieabschnitten vor, das die Identifizierung von krankheitsspezifischen Konformationsvarianten von Alpha-Synuclein ermöglicht, die an der Parkinson-Krankheit und mehreren Proteinen der peripheren Nervensystems.

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Neurowissenschaften Ausgabe 148 Hautbiopsie Peripheres Nervensystem indirekte Immunfluoreszenz Freischwebend Proteingenprodukt 9.5 Alpha Synuclein Phosphoryliertes Alpha Synuclein 5G4 Proteinaggregate
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