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Narkotikascreening av primær pasient avledet tumor xenografts i sebrafisk

Article DOI: 10.3791/60996-v • 09:50 min • April 10th, 2020
April 10th, 2020 •
1,2, 1, 1,2
1Department of Molecular and Cellular Biochemistry, University of Kentucky, 2Markey Cancer Center, University of Kentucky

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Zebrafish xenograft modeller tillate høy gjennomstrømning narkotika screening og fluorescerende avbildning av menneskelige kreftceller i en in vivo mikromiljø. Vi utviklet en arbeidsflyt for storskala, automatisert legemiddelscreening på pasientavledede leukemiprøver i sebrafisk ved hjelp av et automatisert fluorescensmikroskop utstyrt bildeenhet.

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Kreftforskning Utgave 158 sebrafisk pasientavledet xenograft høy gjennomstrømning narkotikaskjerm leukemi automatisert
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