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Neuroscience

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JoVE Journal Neuroscience
Bruke en cellesporerinjeksjon for å undersøke opprinnelsen til neointimadannende celler i en rottesekkulær sideveggmodell
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Bruke en cellesporerinjeksjon for å undersøke opprinnelsen til neointimadannende celler i en rottesekkulær sideveggmodell

Article DOI: 10.3791/63580-v • 05:41 min • March 16th, 2022
March 16th, 2022 •
*1,2, *1,2, 1,2, 1,2, 2, 1,2, 3, 4, 1,2,5, 1,2,5
1Department of Neurosurgery, Kantonsspital Aarau, 2Cerebrovascular Research Group, Department for BioMedical Research, University of Bern, 3Institute of Pathology Laenggasse, 4Department of Neurosurgery, Neurocenter and Regenerative Neuroscience Cluster, Inselspital, Bern University Hospital, University of Bern, 5Faculty of Medicine, University of Bern
* These authors contributed equally

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Vi utførte en ett-punkts, lipofil celle-tracer injeksjon for å spore endotelceller, etterfulgt av en arteriotomi og suturering av sidevegganeurismer på abdominal rotte aorta. Neointimaformasjonen virket avhengig av foreldrearterien i decellulariserte aneurisme og ble fremmet av rekrutteringen fra aneurismeveggceller i vitale cellerike vegger.

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Nevrovitenskap Utgave 181 Helsinki rotte mikrokirurgisk sidevegg aneurisme modell endovascular terapi celle-tracer injeksjon foreldre arterie neointima endotel nevrobiologi
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