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JoVE Journal Biology
Inductie- en diverse beoordelingsindicatoren van experimentele auto-immuun encefalomyelitis
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Inductie- en diverse beoordelingsindicatoren van experimentele auto-immuun encefalomyelitis

Article DOI: 10.3791/63866-v • 06:19 min • September 9th, 2022
September 9th, 2022 •
*1, *1, 1,2, 1, 1, 1, 1, 1, 1, 1, 3, 1
1Putuo People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, 2National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 3Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University
* These authors contributed equally

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Het huidige protocol beschrijft de inductie van experimentele auto-immune encefalomyelitis in een muismodel met behulp van myeline oligodendrocytenglycoproteïne en het monitoren van het ziekteproces met behulp van een klinisch scoresysteem. Experimentele auto-immuun encefalomyelitis-gerelateerde symptomen worden geanalyseerd met behulp van muis femur micro-computertomografie analyse en open veld test om het ziekteproces uitgebreid te beoordelen.

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Biologie Nummer 187 multiple sclerose experimentele auto-immuun encefalomyelitis myeline oligodendrocytenglycoproteïne neuro-inflammatie angstachtig gedrag osteoporose
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