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Medikamentell behandling med sentralt venekateter i musemodell av angiotensin II-indusert abdominal aortaaneurisme og overvåking ved 3D-ultralyd
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Medikamentell behandling med sentralt venekateter i musemodell av angiotensin II-indusert abdominal aortaaneurisme og overvåking ved 3D-ultralyd

Article DOI: 10.3791/64124-v • 10:09 min • August 4th, 2022
August 4th, 2022 •
1, 1, 1, 2,3, 4, 5, 1, 1, 1
1Division of Vascular Surgery, Department of General Surgery, Medical University of Vienna and Vienna General Hospital, 2Leeds Institute for Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, 3Leeds Vascular Institute, Leeds General Infirmary, 4Department for Visceral, Thoracic and Vascular Surgery, Technical University of Dresden and University Hospital Carl-Gustav Carus, 5Division of Cardiovascular and Interventional Radiology, Division of Molecular and Gender Imaging, Department of Biomedical Imaging and Image Guided Therapy, Medical University of Vienna and Vienna General Hospital

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Denne protokollen beskriver den påfølgende implantasjonen av en osmotisk pumpe for å indusere abdominal aortaaneurisme ved angiotensin II-frigjøring i apolipoprotein E (ApoE) mangelfulle mus og av en vaskulær tilgangsport med et jugulært venekateter for gjentatt legemiddelbehandling. Overvåking av aneurismeutvikling ved 3D-ultralyd utføres effektivt til tross for dorsale implantater.

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