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JoVE Journal Chemistry
In vitro og in vivo evaluering af fotokontrollerede biologisk aktive forbindelser - potentielle lægemiddelkandidater til kræft fotofarmakologi
Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Journal (Chemistry)
Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Atom Transfer Radical Polymerization of Functionalized Vinyl Monomers Using Perylene as a Visible Light Photocatalyst
Journal (Chemistry)
Atom Transfer Radical Polymerization of Functionalized Vinyl Monomers Using Perylene as a Visible Light Photocatalyst
 
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In vitro og in vivo evaluering af fotokontrollerede biologisk aktive forbindelser - potentielle lægemiddelkandidater til kræft fotofarmakologi

Article DOI: 10.3791/64902-v • 13:17 min • September 29th, 2023
September 29th, 2023 •
*1,2, *2, 2, 1, 1, 1, 2, 2, 3,4, 3, 4, 3, 1,2,4
1Taras Shevchenko National University of Kyiv, 2Bienta/Enamine, 3Karlsruhe Institute of Technology, 4Lumobiotics
* These authors contributed equally

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Denne protokol præsenterer et sæt eksperimenter vedtaget til evaluering af fotoomskiftelige anticancerpeptider, der kan anvendes til præklinisk screening af sådanne forbindelser. Dette omfatter cytotoksicitetsvurdering i 2D- og 3D-cellekulturer, evaluering af ex vivo (modelvæv) fotoisomeriseringseffektivitet og in vivo-effektivitet .

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Denne måned i JoVE nummer 199
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