Journal
/
Chemie
/
Protokol til syntese af<em> Ortho</em> -trifluoromethoxylated anilinderivater
JoVE Journal
Chemie
Zum Anzeigen dieser Inhalte ist ein JoVE-Abonnement erforderlich.  Melden Sie sich an oder starten Sie Ihre kostenlose Testversion.
JoVE Journal Chemie
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Protokol til syntese af<em> Ortho</em> -trifluoromethoxylated anilinderivater

DOI:
10.3791/53789-v

•

08:43 min

•

January 19, 2016

•

,
1Department of Chemistry,State University of New York at Stony Brook, 2Institute of Chemical Biology and Drug Discovery,State University of New York at Stony Brook

Kapitel

  • 00:05Titel
  • 00:53Precursor Preparation: Synthesis of Methyl 4-(N-hydroxyacetamido) Benzoate
  • 04:33Synthesis of Methyl 4-(N-trifluoromethoxy)acetamido) Benzoate
  • 05:58Synthesis of Methyl 4-Acetamido-3-(trifluoromethoxy) Benzoate via Trifluoromethoxy-migration
  • 07:14Results: Synthesis of Trifluoromethoxylated Aniline Derivatives Using Togni Reagent II
  • 08:12Conclusion

Summary

Automatische Übersetzung

Automatische Übersetzung

An operationally simple procedure for the synthesis of ortho-trifluoromethoxylated aniline derivatives via a two-step sequence of O-trifluoromethylation of N-aryl-N-hydroxyacetamide followed by thermally induced intramolecular OCF3-migration is reported.

Tags

Ortho-trifluoromethoxylated AnilineAniline DerivativesReductionHydrogenationAcetyl ProtectionRhodium CatalystCelite FiltrationTLC MonitoringAnhydrous SolventsNitrogen Atmosphere

Article

Embed

ZUR WIEDERGABELISTE HINZUFÜGEN

Usage Statistics

Verwandte Videos

Syntese af antiviral tetrahydrocarbazol Derivater af fotokemisk og Syre-katalyseret CH Funktionalisering via mellemliggende peroxider (chips)

En Direct, Early Stage Guanidinylation Protokol til syntese af komplekse aminoguanidin-holdige Naturprodukter

En protokol for Produktion af Gliadin-cyanoacrylat Nanopartikler for hydrofile belægning

Syntese af Protein biokonjugater<em> via</em> Cystein-maleimid Kemi

Facile Syntese af ormelignende Miceller af synligt lys Mediated Dispersion polymerisering Brug Photoredox Catalyst

Protokol til fastfasesyntese af oligomerer af RNA indeholdende en 2'-<em> O</em> -thiophenylmethyl-modifikation og karakterisering via cirkulær dikroisme

Syntese og massespektrometri analyse af Oligo-peptoids

MPLEx protokol for Multi-omic analyser af jordprøver

FACILE protokol til syntese af selvstændige montage Polyamine-baserede peptid Amphiphiles (elkøbsaftalerne) og relaterede biomaterialer

Automatisering af en Positron-emissions-tomografi (PET) Radiotracer syntese protokol for kliniske produktion

Read Article