Rivista
/
Chimica
/
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
JoVE Journal
Chimica
È necessario avere un abbonamento a JoVE per visualizzare questo.  Accedi o inizia la tua prova gratuita.
JoVE Journal Chimica
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

DOI:
10.3791/53789-v

•

08:43 min

•

January 19, 2016

•

,
1Department of Chemistry,State University of New York at Stony Brook, 2Institute of Chemical Biology and Drug Discovery,State University of New York at Stony Brook

Capitoli

  • 00:05Titolo
  • 00:53Precursor Preparation: Synthesis of Methyl 4-(N-hydroxyacetamido) Benzoate
  • 04:33Synthesis of Methyl 4-(N-trifluoromethoxy)acetamido) Benzoate
  • 05:58Synthesis of Methyl 4-Acetamido-3-(trifluoromethoxy) Benzoate via Trifluoromethoxy-migration
  • 07:14Results: Synthesis of Trifluoromethoxylated Aniline Derivatives Using Togni Reagent II
  • 08:12Conclusion

Summary

Traduzione automatica

Traduzione automatica

An operationally simple procedure for the synthesis of ortho-trifluoromethoxylated aniline derivatives via a two-step sequence of O-trifluoromethylation of N-aryl-N-hydroxyacetamide followed by thermally induced intramolecular OCF3-migration is reported.

Tags

Ortho-trifluoromethoxylated AnilineAniline DerivativesReductionHydrogenationAcetyl ProtectionRhodium CatalystCelite FiltrationTLC MonitoringAnhydrous SolventsNitrogen Atmosphere

Article

Embed

AGGIUNGI ALLA PLAYLIST

Usage Statistics

Video correlati

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

A Protocol for the Production of Gliadin-cyanoacrylate Nanoparticles for Hydrophilic Coating

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2′-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids

The MPLEx Protocol for Multi-omic Analyses of Soil Samples

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials

Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production

Read Article