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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
 

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Article DOI: 10.3791/53789
January 19th, 2016

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Summary January 19th, 2016

An operationally simple procedure for the synthesis of ortho-trifluoromethoxylated aniline derivatives via a two-step sequence of O-trifluoromethylation of N-aryl-N-hydroxyacetamide followed by thermally induced intramolecular OCF3-migration is reported.

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