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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Article DOI: 10.3791/61644-v • 09:36 min • September 24th, 2020
September 24th, 2020 •
1,2, 1,2, 1,2, 1,2, 1,2, 2, 2, 2, 1, 1,2, 1, 3, 2,4, 1,2,5
1Department of Perioperative Medicine, CHU Clermont-Ferrand, 2GReD, CNRS, INSERM, Université Clermont Auvergne, 3GRC 29, AP-HP, DMU DREAM, Department of Anesthesiology and Critical Care, Pitié-Salpêtrière Hospital, Sorbonne University, 4Department of Biochemistry and Molecular Genetics, CHU Clermont-Ferrand, 5Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center

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Summary
Automatic Translation

We describe a model of hydrochloric acid-induced acute respiratory distress syndrome (ARDS) in piglets receiving sedation with halogenated agents, isoflurane and sevoflurane, through a device used for inhaled intensive care sedation. This model can be used to investigate the biological mechanisms of halogenated agents on lung injury and repair.

Tags

Halogenated Agent Delivery Acute Respiratory Distress Syndrome Intensive Care Unit Lung Injury Mechanism Novel Therapy Inhaled Anesthetics Aesthetic Conserving Device ICU Sedation Translational Opportunities Effects Of Halogenated Agents Pedal Reflex Surgical Exposure Internal Jugular Vein Seldinger Method Central Venous Access Cutaneous Midline Incision Trachea Surgical Forceps Puncture Guidewire Venous Catheter
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