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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Article DOI: 10.3791/50398-v • 08:50 min • July 3rd, 2013
July 3rd, 2013 •
1, 1, 1, 1
1Department of Nephrology & Hypertension, University Medical Center Utrecht

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A two-stage method to establish chronic kidney disease (CKD) in the Lewis rat by surgically removing 5/6th of renal mass is described. Combination of the surgical procedure, NOS-inhibition and a high-salt diet leads to a model resembling human CKD, allowing study of causal mechanisms and development of novel therapeutic interventions.

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5/6th Nephrectomy High Salt Diet Nitric Oxide Synthase Inhibition Chronic Kidney Disease CKD Integrative Animal Models Renal Disease Glomerular And Tubulo-interstitial Injury Remnant Nephrons Systemic And Glomerular Hypertension Intrarenal Capillary Loss Inflammation Glomerulosclerosis Endothelial Function NG-nitro-L-Arginine L-NNA Uninephrectomy Subtotal Nephrectomy
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