Name: hypoxia: types and carbon monoxide poisoning
Uploaded: 2024-09-12T13:22:46.000Z
Duration: 1 min 23 s
Channel: JoVE

K12 Standards

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Ohio’s Learning Standards and Model Curriculum

9-12

Human Anatomy and Physiology

Absorption And Excretion

Respiratory System

Hypoxia

L'ipossia è una condizione in cui i tessuti del corpo non ricevono un adeguato apporto di ossigeno. Può essere classificato in quattro tipi distinti.
L'ipossia anemica si verifica a causa di una carenza di globuli rossi o quando i globuli rossi contengono un'emoglobina anormale o insufficiente, con conseguente scarso apporto di ossigeno.
L'ipossia ischemica deriva da una ridotta o ostruita circolazione sanguigna nei tessuti, che impedisce un'efficiente erogazione di ossigeno.
Nell'ipossia istossica, le cellule non possono utilizzare in modo efficiente l'ossigeno erogato a causa delle tossine, come il cianuro.
Infine, l'ipossia ipossiemica è caratterizzata da una bassa pressione parziale di ossigeno nel sangue arterioso, con possibili cause tra cui malattie polmonari e respirazione di aria con basso contenuto di ossigeno.
Un caso speciale di ipossia ipossiemica è il monossido di carbonio o avvelenamento da CO.
Quando inalato, il CO si lega all'emoglobina con maggiore affinità rispetto all'ossigeno, spostando l'ossigeno dai suoi siti di legame e riducendo la pressione parziale dell'ossigeno nel sangue arterioso.
L'ipossia può essere rilevata attraverso una colorazione bluastra sulla pelle e sulle mucose, particolarmente visibile nei letti ungueali.

ipossia

L’ipossia è una condizione medica caratterizzata da un inadeguato apporto di ossigeno ai tessuti del corpo. Si manifesta tipicamente come una colorazione bluastra della pelle e delle mucose, soprattutto negli individui di carnagione chiara, quando la saturazione dell'emoglobina (Hb) scende al di sotto del 75%.

Tipi di ipossia

Esistono quattro tipi principali di ipossia, ciascuno derivante da una causa diversa:

<ol>
	<li>Ipossia anemica: questo tipo si verifica a causa di un apporto insufficiente di ossigeno causato dalla mancanza di globuli rossi (RBC) o di globuli rossi con Hb anormale o insufficiente.</li>
	<li>Ipossia ischemica: causata da una circolazione sanguigna compromessa o ostruita, che porta a un flusso sanguigno stagnante.</li>
	<li>Ipossia istotossica: si verifica quando le cellule del corpo non possono utilizzare l'ossigeno disponibile, spesso a causa della presenza di veleni metabolici come il cianuro.</li>
	<li>Ipossia ipossiemica: caratterizzata da una ridotta pO_2 arteriosa, può derivare da un accoppiamento anomalo ventilazione-perfusione, da malattie polmonari che influenzano la ventilazione o dalla respirazione di aria con un basso contenuto di ossigeno.</li>
</ol>

Avvelenamento da monossido di carbonio

Un tipo specifico di ipossiemia, l'avvelenamento da monossido di carbonio, è una delle principali cause di morte per incendio. Il monossido di carbonio (CO), un gas inodore e incolore, si lega all'Hb più di 200 volte più fortemente dell'ossigeno, riducendo significativamente la capacità dell'Hb di trasportare ossigeno. Anche tracce di CO possono causare grave ipossia. Il trattamento per l'avvelenamento da CO prevede l'uso di ossigeno al 100% a pressione atmosferica normale o camere iperbariche di ossigeno, che forniscono al paziente livelli di ossigeno superiori al normale, spostando efficacemente la CO dall'Hb. Questo metodo fornisce una soluzione salvavita a un problema altrimenti letale.

Ipossia

L'ipossia è una condizione in cui i tessuti del corpo non ricevono un adeguato apporto di ossigeno. Può essere classificato in quattro tipi distinti.
Ipossia anemica ...

Education

Didattica

JoVE Core

Anatomy and Physiology

Anatomia e Fisiologia

Unit 1

Unità 1

The Respiratory System

L'apparato respiratorio

KEY TERMS AND CONCEPTS

TERMINI E CONCETTI CHIAVE

hypoxia: types and carbon monoxide poisoning

Hypoxia is a medical condition in which body tissues do not get enough oxygen. It can cause a bluish color in the skin and mucosae, especially in fair-skinned people. This sign is often seen when hemoglobin (Hb) saturation drops below 75%.

Hypoxia can happen for several different reasons. Anemic hypoxia occurs when there are too few red blood cells (RBCs) or when RBCs have abnormal or too little Hb. Ischemic hypoxia comes from poor blood circulation or blocked blood flow, so blood becomes stagnant.

Another form is histotoxic hypoxia. In this case, body cells cannot use the oxygen that is available. Metabolic poisons such as cyanide can cause this problem. Hypoxemic hypoxia is different because it involves reduced arterial pO2, which can result from abnormal ventilation-perfusion coupling, pulmonary disease that affects ventilation, or breathing air with low oxygen content.

Carbon monoxide poisoning is a special form of hypoxemic hypoxia and is a leading cause of death from fires. Carbon monoxide (CO) is odorless and colorless. It binds to Hb more than 200 times more strongly than oxygen, so even small amounts can sharply reduce Hb's ability to carry oxygen. Treatment includes 100% oxygen at normal atmospheric pressure or oxygen in hyperbaric chambers, which helps displace CO from Hb and can save a life.

Hypoxia: Types and Carbon Monoxide Poisoning

hypoxia-types-and-carbon-monoxide-poisoning

overview of respiratory system

How Breathing Moves Air and Gases

The respiratory system moves air in and out of the body and exchanges oxygen and carbon dioxide with the environment. This gas exchange is part of respiration, which is essential for life. The system supplies the blood with oxygen so it can carry that oxygen to the rest of the body. Breathing starts when air enters through the nose or mouth. The nose and nasal cavity form the main external opening and the first part of the airway. Air then passes through the pharynx, or throat, which is shared...

nose and nasal cavity

How the Nose Filters and Senses Air

The nose filters, warms, moistens, and senses the air that enters the body. It also helps shape speech as sound vibrations pass through its large air spaces. The nose has an external part that is visible on the face and an internal part called the nasal cavity. The external nose is built from bone and hyaline cartilage, which gives it flexibility. It is covered by skin and muscle and lined with a mucous membrane. The frontal bone, nasal bones, and maxillary bone support this structure. The...

pharynx

Pharynx Pathways for Air and Food

The pharynx is a muscular tube lined with mucous membrane that connects the nasal cavities to the throat. It is divided into three parts: the nasopharynx, oropharynx, and laryngopharynx. Each part has a different role in moving air and food through the upper throat. The nasopharynx sits behind the nasal cavity and serves only as an air passage. Its upper region contains the pharyngeal tonsils, also called adenoids. These are clusters of lymphoid reticular tissue, similar to a lymph node, and...

larynx

Voice Box Anatomy and Function

The larynx is the voice box in the neck. It carries air into the lungs and helps produce voice. Its structure is complex because it must support both breathing and sound production. The larynx contains cartilage, muscles, and the vocal cords, also called vocal folds. It includes three large unpaired cartilages: the thyroid, cricoid, and epiglottis. It also includes three paired cartilages: the arytenoids, corniculates, and cuneiforms. Ligaments and membranes hold these parts together. The...

trachea

Trachea: Layers, Rings, and Airflow

The trachea is the windpipe, and it is a key airway in the human respiratory system. It carries air between the larynx and the bronchi so oxygen can reach the lungs. About half of the trachea lies in the neck, and it sits in front of the esophagus. In an average adult, the trachea is about 10 to 12 cm long. It extends from the larynx at the level of the sixth cervical vertebra to the level of the fifth thoracic vertebra. Its wall is supported by C-shaped cartilaginous rings. The back side is...

the bronchial tree

Bronchial Branching and Airflow Control

The bronchial tree carries air from the trachea into the lungs and helps control breathing. The trachea, or windpipe, connects the larynx to the bronchi. At the carina, the trachea splits into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left. Because of that shape, foreign objects and infections are more likely to enter the right lung. The carina is a cartilaginous ridge at the split in the airway. It helps keep the airway open. It also has...

alveoli and alveolar ducts

How Alveoli Enable Gas Exchange

The respiratory zone of the human body is where gas exchange happens. It begins when the terminal bronchioles branch into respiratory bronchioles, the smallest bronchiole type. These then lead into alveolar ducts and finally into clusters of alveoli. Alveoli are tiny air sacs that look like bunches of grapes. They connect to alveolar ducts, and a group of alveoli forms an alveolar sac. A single alveolus is about 200 μm wide, and its elastic shape lets it expand during inhalation. Nearby...

gross anatomy of the lungs

Lung Lobes, Airways, and Blood Flow

The lungs are paired organs that connect to the trachea through the left and right bronchi. Their base rests against the diaphragm, the dome-shaped muscle below the lungs. The lungs are covered by the pleurae and sit next to the mediastinum, the central space in the chest. The right lung is shorter and wider than the left lung, and it has a larger volume. The left lung has a cardiac notch, which is an indentation for the heart. The top of each lung is the apex, and the lower part is the base.

pleura of the lungs

Pleura Layers and Lung Protection

The pleura are membranes that protect the lungs inside the chest cavity. They are a type of serous membrane and wrap around each lung. The pleura have two layers: the visceral pleura and the parietal pleura. The visceral pleura covers the surface of the lung. The parietal pleura is the outer layer. It lines the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point where the visceral and parietal layers connect. The space between these layers is called the pleural cavity. <br...

pressure relationships in thoracic cavity

pressure-relationships-in-thoracic-cavity

How Pressure Drives Breathing in the Lungs

Breathing depends on pressure changes in the lungs, chest, and airways. Pulmonary ventilation is the movement of air into and out of the lungs. It is driven by atmospheric pressure, intra-alveolar pressure inside the alveoli, and intrapleural pressure in the pleural cavity. Inhalation and exhalation rely on pressure differences between the atmosphere and the lungs. Gas pressure comes from the movement of confined molecules. Boyle’s law explains that pressure and volume are inversely...

pulmonary ventilation: inhalation

Pulmonary Ventilation and Breathing Pressures

Pulmonary ventilation depends on breathing movements and the pressure changes that move air into and out of the lungs. It supports the exchange of oxygen and carbon dioxide by letting the body take in oxygen and remove waste carbon dioxide. Boyle's law is important here because changes in volume and pressure affect how air moves in the respiratory system. Several respiratory volumes help describe how much air the lungs move. Tidal volume is the air inspired or expired during normal, quiet...

pulmonary cycle: exhalation

Exhalation and Lung Pressure Changes

Exhalation is the process of expelling air from the lungs. It depends on pressure differences between the lungs and the atmosphere. During normal quiet breathing, exhalation is passive and does not require muscle contraction. The elastic recoil of the lungs and chest wall helps both structures return to their resting positions after inhalation. When the muscles used for inhalation stop working, the diaphragm and external intercostal muscles relax. The diaphragm moves upward, and the ribs move...

factors affecting pulmonary ventilation

What Changes Breathing Ease in the Lungs

Breathing ease in the lungs depends on alveolar surface tension, lung compliance, and airway resistance. These factors affect how hard it is to move air during pulmonary ventilation, along with the pressure difference between the outside environment and the lungs. Alveolar surface tension comes from the fluid lining the inside of the alveoli. Water molecules in this fluid attract each other more strongly than they attract the air, so the liquid tends to pull the alveoli inward. That force must...

respiratory volumes and capacities

Lung Volume Measurements in Breathing

Lung volume measurements show how air moves in and out of the respiratory system during breathing. They help explain how the body takes in oxygen and removes carbon dioxide. Respiratory volumes and capacities also give useful information about lung function. Tidal volume is the air breathed in and out during normal, quiet breathing. Inspiratory reserve volume is the extra air that can be forcefully inhaled beyond tidal volume. Expiratory reserve volume is the extra air that can be forcefully...

physical principles governing gas exchange

physical-principles-governing-gas-exchange

Gas Laws in Lung Gas Exchange

Gas laws explain how oxygen and carbon dioxide move during respiration. External respiration is the exchange of gases in the lungs. Oxygen diffuses into the blood, and carbon dioxide diffuses out. Internal respiration happens in body tissues, where the gases move in the opposite directions. Two gas laws guide this process: Dalton's law of partial pressures and Henry's law. Dalton's law says the total pressure of a gas mixture equals the sum of the pressures of each gas acting alone. The...

external and internal respiration

Gas Exchange in Lungs and Tissues

Gas exchange in the lungs and body tissues moves oxygen into the blood and removes carbon dioxide. External respiration happens in the lungs, where inhaled oxygen enters the alveoli, the tiny air sacs that provide a large surface area for diffusion. Oxygen moves across the thin alveolar membrane into the pulmonary capillaries because its partial pressure is higher in the alveoli than in the blood. At the same time, carbon dioxide moves in the opposite direction and is later breathed out during...

oxygen transport in the blood

How Hemoglobin Loads and Releases Oxygen

Hemoglobin is the main molecule that carries oxygen in blood. It is found in red blood cells and has four polypeptide chains, each attached to an iron-containing heme group. This structure lets one hemoglobin molecule bind up to four oxygen molecules quickly and reversibly. When hemoglobin is fully loaded with oxygen, it is called oxyhemoglobin. When it has released oxygen, it is called reduced hemoglobin, or deoxyhemoglobin. As hemoglobin binds oxygen, its shape changes, which helps it pick...

carbon dioxide transport in the blood

How Blood Carries Carbon Dioxide

Carbon dioxide is carried in the blood from body tissues to the lungs. Cells make about 200 mL of CO2 each minute, and the lungs remove about the same amount. The blood moves this waste gas in three main forms. A small amount, about 7-10%, stays dissolved in the plasma. Just over 20% binds to hemoglobin and forms carbaminohemoglobin. In this case, CO2 attaches to the amino acids of globin, not to the heme part of hemoglobin. The rest, about 70%, is carried as bicarbonate ions, or HCO3-. CO2...

hypoxia

Hypoxia is a medical condition in which body tissues do not get enough oxygen. It can cause a bluish color in the skin and mucosae, especially in fair-skinned people. This sign is often seen when hemoglobin (Hb) saturation drops below 75%. Hypoxia can happen for several different reasons. Anemic hypoxia occurs when there are too few red blood cells (RBCs) or when RBCs have abnormal or too little Hb. Ischemic hypoxia comes from poor blood circulation or blocked blood flow, so blood becomes...

neural control of respiration

Brainstem Centers That Control Breathing

Breathing is controlled by nerve centers in the brainstem. These respiratory centers send nerve signals to the muscles that move the lungs. The main centers are in the medulla oblongata and the pons.

chemical factors affecting respiration centers

chemical-factors-affecting-respiration-centers

How Blood Gases Control Breathing Rate

Blood gases and blood pH help control breathing rate and depth. Changes in carbon dioxide, oxygen, and hydrogen ion levels in arterial blood are detected by chemoreceptors, which are special sensors in the body. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla. Peripheral chemoreceptors are located in the aortic arch and carotid arteries. Together, these sensors help the respiratory system respond to chemical changes in the blood. Carbon dioxide...

other factors affecting respiration centers

other-factors-affecting-respiration-centers

Respiratory Reflexes That Change Breathing

Breathing is controlled by the brainstem, but it can also be changed by the nervous system and by body signals. The cerebral motor cortex can override the medullary respiratory centers and send signals directly to the breathing muscles. This makes voluntary actions like holding your breath or taking deeper breaths possible. That control is limited. When carbon dioxide, or CO2, builds up in the blood to a critical level, the brainstem respiratory centers start breathing again. This is why a...

hyperpnea and hyperventilation

Breathing Changes in Exercise and Anxiety

Breathing changes in exercise and anxiety can look similar, but they do not have the same cause. Hyperventilation is a higher-than-normal rate and depth of breathing. It often happens during anxiety attacks and can push out more carbon dioxide than the body needs to remove. When too much carbon dioxide is lost, the blood develops hypocapnia, which means an unusually low level of carbon dioxide. Hypocapnia can narrow cerebral blood vessels and reduce blood flow to the brain. This may cause...

chronic obstructive pulmonary disease

COPD Signs, Causes, and Lung Damage

COPD is a lung condition that causes ongoing breathing problems. It leads to shortness of breath, cough, and sputum production because the airways become blocked and airflow is reduced. Smoking is the main risk factor for COPD, and more than 80% of patients have a history of it. People with COPD often develop worsening dyspnea, or labored breathing. They may also cough often and get repeated lung infections. Many patients with COPD can develop respiratory failure. This happens when...

other pulmonary disorders

Asthma, TB, Lung Cancer, and Sleep Apnea

Asthma, lung cancer, tuberculosis, and sleep apnea are major pulmonary disorders. They affect breathing in different ways. Some are chronic, some are infectious, and some can become life-threatening if not found and treated early. Asthma is marked by chronic airway inflammation and hypersensitivity. It can cause airway obstruction from bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Triggers vary and can include allergens or emotional upset. Treatment often...

key terms and concepts

Learn the main types of hypoxia, how low oxygen affects tissues, and why carbon monoxide poisoning can block hemoglobin and require emergency oxygen treatment.

Hypoxia: Types and Carbon Monoxide Poisoning | JoVE K12

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JoVE Core Anatomy and Physiology showcases the anatomical and physiological details of the human body in comprehensive, clear, and engaging video animations. This collection of lessons focuses on the structures, components, functions, and requirements of the human body. It is complemented by scientist-in-action videos that demonstrate the application of this knowledge in real-world medical and research settings.

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These cells first synthesize carbonic acid, which ...

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Digestive System

Hypoxia: Types and Carbon Monoxide Poisoning

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