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Pseudofracture: An Acute Peripheral Tissue Trauma Model
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JoVE Journal Medicina
Pseudofracture: An Acute Peripheral Tissue Trauma Model

Pseudofracture: An Acute Peripheral Tissue Trauma Model

DOI:
10.3791/2074-v

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10:08 min

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April 18, 2011

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, , , , ,
1Department of Surgery,University of Pittsburgh, 2Department of Orthopedic Surgery,University of Aachen Medical Center

Capitoli

  • 00:05Titolo
  • 00:49Introduction
  • 01:16Preparation of a Bone Solution
  • 06:05Surgical Procedure Pseudofracture Model = Soft Tissue Injury and Bone Solution Injection
  • 08:45Representative Results of Immune Responses Following Trauma
  • 09:49Conclusion

Summary

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Traduzione automatica

Pseudofracture, a reproducible murine model of sterile musculoskeletal trauma, allows for evaluation of late term post-traumatic immune responses. This article describes the procedural execution of the model step by step, including the potential for experimental model combinations to permit study of multiple trauma.

Tags

PseudofractureHyper-reactive Inflammatory ResponseMultiple Organ DysfunctionHigh MortalityDelayed ImmunosuppressionClinical ComplicationsInfectionMortalityImmunologic StudiesTransgenic MiceKnockout MiceIn Vivo ModelingMolecular PathwaysFracture Fixation TechniquesPseudofracture ModelExtremity Fracture EnvironmentDamaged Bone And Bone Marrow

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