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Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease

Article DOI: 10.3791/54868-v • 09:33 min • December 26th, 2016
December 26th, 2016 •
1, 1, 1
1Zilkha Neurogenetic Institute, University of Southern California (USC)

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We developed a methodology for quantitative 3D in silico modeling (q3DISM) of cerebral amyloid-β (Aβ) phagocytosis by mononuclear phagocytes in rodent models of Alzheimer's disease. This method can be generalized for the quantitation of virtually any phagocytic event in vivo.

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Quantitative 3D In Silico Modeling Q3DISM Cerebral Amyloid-beta Phagocytosis Rodent Models Alzheimer's Disease Uptake Of Amyloid-beta Mononuclear Phagocytes Senile Plaques 3D Reconstruction Quantitation Macrophages Microphage Phagocytosis Experimental Alzheimer's Disease Therapeutics Hydrophobic Barrier Pen Immunostaining Blocking Buffer Primary Antibody
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