Name: pulmonary ventilation and breathing pressures
Uploaded: 2025-05-22T09:06:19.000Z
Duration: 1 min 24 s
Channel: JoVE

K12 Standards

ohios-learning-standards-and-model-curriculum

Ohio’s Learning Standards and Model Curriculum

9-12

Human Anatomy and Physiology

Absorption And Excretion

Respiratory System

Pulmonary Ventilation: Inhalation

呼吸は、吸気と呼気を交互に繰り返すリズミカルなプロセスです。
静かな吸入では、肺内のガス圧の低下により胸腔が拡張し、空気が流入します。
横隔膜は、吸入に最も重要な筋肉です。約1cm収縮して下降し、平らになるため、胸腔の高さが増し、約1〜3mmHgの圧力差が生じます。
外肋間筋の収縮により、胸郭が持ち上げられ、胸骨が上に引っ張られます。
肋骨は外側に突き出ており、胸部の直径を横方向および前後方向に拡大します。
胸部の寸法は数ミリしか変化しませんが、胸部の容積は約500ml増加します。
胸部の寸法が大きくなると、肺内容積が増加し、肺内圧が大気圧より約1mmHg低下します。
肺内圧が大気圧と等しくなるまで、空気が肺に流れ込みます。同時に、胸膜内圧は大気圧に対して約-6mmHgに低下します。

肺換気「吸気」

肺換気は、肺での酸素と二酸化炭素の交換を確実にする重要なプロセスです。肺への空気の出入りを指し、これにより体は酸素を得て、不要な二酸化炭素を排出することができます。この記事では、肺換気の根底にある原理、メカニズム、呼吸器系内の圧力の相互作用など、肺換気の複雑さについて説明します。

ボイルの法則は、呼吸量と呼吸圧を調べるときに特に重要になります。肺換気の文脈では、いくつかの重要な用語を理解することが重要です。

一回換気量（TV）とは、通常の呼吸中に意識的な努力なしに吸い込んだり吐き出したりする空気の量を指します。

予備吸気量（IRV）は、一回換気量を超えて強制的に吸入できる空気の最大量です。

予備呼気量（ERV）：一回換気量を超えて強制的に吐き出すことができる空気の最大量。

残気量（RV）：最大呼気後に肺に残る空気の量。

これらの呼吸量は、肺活量などの重要な指標の計算に貢献します。

肺活量（VC）は、一回換気量、予備吸気量、予備呼気量の合計です。

さらに、呼吸量と圧力の関係は複雑に絡み合っています。通常の吸気（吸入）時には、横隔膜と外肋間筋が収縮し、胸腔が拡張します。この拡張により肺の容積が増加し、肺内圧が低下して空気が大気から肺に流れ込むようになります。

吸気（吸入）の仕組み

吸入は、横隔膜、肋間筋、胸腔の拡張を伴う一連の相互に関連したプロセスによって起こります。各ステップを詳しく見てみましょう。

<ol>
	<li>横隔膜の収縮: 通常の吸入時に関与する主な筋肉は横隔膜です。このドーム型の筋肉は、胸腔と腹腔を隔てています。吸入すると、横隔膜が収縮して平らになり、胸腔の容積が増加します。この動作により肺内に負圧が生じ、空気が肺に引き込まれます。</li>
	<li>肋間筋の働き: 肋間筋は、吸入に関係するもう 1 つの重要な筋肉群です。肋骨の間に位置し、外肋間筋と内肋間筋に分かれています。
	外肋間筋: 吸入時に、これらの筋肉は収縮し、胸郭を持ち上げて拡張します。この動きにより胸腔の容積がさらに増加し​​、空気の吸入量が増加します。

	内肋間筋: これらの筋肉は、深い吸入と強制的な呼気を補助します。強制吸入中は、上部内肋間筋が収縮し、胸郭がさらに上昇して、肺の拡張が大きくなります。
	</li>
	<li>胸腔の拡張: 横隔膜が収縮し、肋間筋が働くと、胸腔は複数の方向に拡張します。この拡張により肺内の圧力が低下し、外気と呼吸器系内の空気の間に圧力差が生じます。その結果、空気が肺に流れ込み、ガス交換のために肺胞 (小さな気嚢) を満たします。</li>
</ol>

強制吸気: 身体活動が増すときや酸素摂取量を増やす必要があるときには、強制吸入が行われます。強制吸入の仕組みには、肺の拡張を最大限にするために追加の筋肉が関与します。

<ol>
	<li>胸鎖乳突筋: 首にある胸鎖乳突筋は、強制吸入において重要な役割を果たします。この筋肉が活性化されると、胸骨が持ち上がり、胸腔のさらなる拡張を助けます。</li>
	<li>斜角筋: 首の両側にある斜角筋は、強制吸気時に上部の肋骨を持ち上げます。この筋肉が収縮すると、肺が拡張するためのスペースが広がります。</li>
	<li>小胸筋：大胸筋の下にある小胸筋は、肋骨を持ち上げて胸腔を広げるのに役立ちます。</li>
</ol>

肺換気における圧力の役割

適切な肺換気は、3 つの異なる圧力の相互作用に依存します。

<ol>
	<li>肺内圧: 肺胞圧とも呼ばれ、肺内部の圧力を指します。吸気中は肺内圧が低下し、空気が肺に流れ込みます。一方、呼気中は肺内圧が上昇し、空気の排出が促進されます。</li>
	<li>胸腔内圧: この圧力は、壁側胸膜と臓側胸膜の間の空間内に存在します。通常、この圧力は、肺の収縮と胸壁の膨張の間の力のバランスにより、大気圧や肺内圧よりも低く、胸壁に対して肺が膨張した状態が維持されます。胸腔内圧が変化すると、肺虚脱やその他の呼吸器系の問題につながる可能性があります。</li>
	<li>大気圧: 大気圧は、地球の大気が任意の場所で及ぼす圧力です。肺内圧を測定する基準として機能します。吸気 (吸入) 時には、肺内圧が大気圧より低くなるため空気が入りやすくなり、呼気時には肺内圧が大気圧より高くなるため空気が肺から排出されます。</li>
</ol>

呼吸は、吸気と呼気を交互に繰り返すリズミカルなプロセスです。
静かな吸入中、胸腔は減少により拡張します...

Education

JoVE Core

Anatomy and Physiology

解剖生理学

Unit 1

ユニット1

The Respiratory System

呼吸器系

KEY TERMS AND CONCEPTS

主要用語と概念

pulmonary ventilation and breathing pressures

Pulmonary ventilation depends on breathing movements and the pressure changes that move air into and out of the lungs. It supports the exchange of oxygen and carbon dioxide by letting the body take in oxygen and remove waste carbon dioxide. Boyle's law is important here because changes in volume and pressure affect how air moves in the respiratory system.

Several respiratory volumes help describe how much air the lungs move. Tidal volume is the air inspired or expired during normal, quiet breathing. Inspiratory reserve volume is the extra air that can be forcefully inhaled after a normal breath, while expiratory reserve volume is the extra air that can be forcefully exhaled after a normal breath. Residual volume is the air that remains in the lungs after maximal expiration. These values are used to calculate vital capacity, which is the sum of tidal volume, inspiratory reserve volume, and expiratory reserve volume.

Normal inhalation begins when the diaphragm contracts and the external intercostal muscles contract. The diaphragm is a dome-shaped muscle that separates the thoracic cavity from the abdominal cavity, and when it flattens, the chest cavity gets larger. The external intercostal muscles lift and expand the rib cage, which also increases thoracic volume. As the chest cavity expands, intrapulmonary pressure falls and air flows from the atmosphere into the lungs.

Forced inhalation uses additional muscles when the body needs more oxygen, such as during physical exertion. The sternocleidomastoid muscle in the neck raises the sternum. The scalene muscles on either side of the neck lift the upper ribs. The pectoralis minor also helps raise the ribs and expand the chest cavity even more.

Breathing also depends on three related pressures. Intrapulmonary pressure, also called alveolar pressure, is the pressure inside the lungs. It drops during inspiration and rises during expiration. Intrapleural pressure is the pressure in the pleural cavity, between the parietal and visceral pleurae. It is usually lower than atmospheric and intrapulmonary pressure because of the balance between lung recoil and chest wall expansion, which helps keep the lungs expanded against the chest wall. If intrapleural pressure changes too much, lung collapse or other breathing problems can result. Atmospheric pressure is the pressure of the air around us, and it serves as the reference point for the pressure changes that move air in and out of the lungs.

Pulmonary Ventilation and Breathing Pressures

pulmonary-ventilation-and-breathing-pressures

overview of respiratory system

How Breathing Moves Air and Gases

The respiratory system moves air in and out of the body and exchanges oxygen and carbon dioxide with the environment. This gas exchange is part of respiration, which is essential for life. The system supplies the blood with oxygen so it can carry that oxygen to the rest of the body. Breathing starts when air enters through the nose or mouth. The nose and nasal cavity form the main external opening and the first part of the airway. Air then passes through the pharynx, or throat, which is shared...

nose and nasal cavity

How the Nose Filters and Senses Air

The nose filters, warms, moistens, and senses the air that enters the body. It also helps shape speech as sound vibrations pass through its large air spaces. The nose has an external part that is visible on the face and an internal part called the nasal cavity. The external nose is built from bone and hyaline cartilage, which gives it flexibility. It is covered by skin and muscle and lined with a mucous membrane. The frontal bone, nasal bones, and maxillary bone support this structure. The...

pharynx

Pharynx Pathways for Air and Food

The pharynx is a muscular tube lined with mucous membrane that connects the nasal cavities to the throat. It is divided into three parts: the nasopharynx, oropharynx, and laryngopharynx. Each part has a different role in moving air and food through the upper throat. The nasopharynx sits behind the nasal cavity and serves only as an air passage. Its upper region contains the pharyngeal tonsils, also called adenoids. These are clusters of lymphoid reticular tissue, similar to a lymph node, and...

larynx

Voice Box Anatomy and Function

The larynx is the voice box in the neck. It carries air into the lungs and helps produce voice. Its structure is complex because it must support both breathing and sound production. The larynx contains cartilage, muscles, and the vocal cords, also called vocal folds. It includes three large unpaired cartilages: the thyroid, cricoid, and epiglottis. It also includes three paired cartilages: the arytenoids, corniculates, and cuneiforms. Ligaments and membranes hold these parts together. The...

trachea

Trachea: Layers, Rings, and Airflow

The trachea is the windpipe, and it is a key airway in the human respiratory system. It carries air between the larynx and the bronchi so oxygen can reach the lungs. About half of the trachea lies in the neck, and it sits in front of the esophagus. In an average adult, the trachea is about 10 to 12 cm long. It extends from the larynx at the level of the sixth cervical vertebra to the level of the fifth thoracic vertebra. Its wall is supported by C-shaped cartilaginous rings. The back side is...

the bronchial tree

Bronchial Branching and Airflow Control

The bronchial tree carries air from the trachea into the lungs and helps control breathing. The trachea, or windpipe, connects the larynx to the bronchi. At the carina, the trachea splits into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left. Because of that shape, foreign objects and infections are more likely to enter the right lung. The carina is a cartilaginous ridge at the split in the airway. It helps keep the airway open. It also has...

alveoli and alveolar ducts

How Alveoli Enable Gas Exchange

The respiratory zone of the human body is where gas exchange happens. It begins when the terminal bronchioles branch into respiratory bronchioles, the smallest bronchiole type. These then lead into alveolar ducts and finally into clusters of alveoli. Alveoli are tiny air sacs that look like bunches of grapes. They connect to alveolar ducts, and a group of alveoli forms an alveolar sac. A single alveolus is about 200 μm wide, and its elastic shape lets it expand during inhalation. Nearby...

gross anatomy of the lungs

Lung Lobes, Airways, and Blood Flow

The lungs are paired organs that connect to the trachea through the left and right bronchi. Their base rests against the diaphragm, the dome-shaped muscle below the lungs. The lungs are covered by the pleurae and sit next to the mediastinum, the central space in the chest. The right lung is shorter and wider than the left lung, and it has a larger volume. The left lung has a cardiac notch, which is an indentation for the heart. The top of each lung is the apex, and the lower part is the base.

pleura of the lungs

Pleura Layers and Lung Protection

The pleura are membranes that protect the lungs inside the chest cavity. They are a type of serous membrane and wrap around each lung. The pleura have two layers: the visceral pleura and the parietal pleura. The visceral pleura covers the surface of the lung. The parietal pleura is the outer layer. It lines the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point where the visceral and parietal layers connect. The space between these layers is called the pleural cavity. <br...

pressure relationships in thoracic cavity

pressure-relationships-in-thoracic-cavity

How Pressure Drives Breathing in the Lungs

Breathing depends on pressure changes in the lungs, chest, and airways. Pulmonary ventilation is the movement of air into and out of the lungs. It is driven by atmospheric pressure, intra-alveolar pressure inside the alveoli, and intrapleural pressure in the pleural cavity. Inhalation and exhalation rely on pressure differences between the atmosphere and the lungs. Gas pressure comes from the movement of confined molecules. Boyle’s law explains that pressure and volume are inversely...

pulmonary ventilation: inhalation

Pulmonary ventilation depends on breathing movements and the pressure changes that move air into and out of the lungs. It supports the exchange of oxygen and carbon dioxide by letting the body take in oxygen and remove waste carbon dioxide. Boyle's law is important here because changes in volume and pressure affect how air moves in the respiratory system. Several respiratory volumes help describe how much air the lungs move. Tidal volume is the air inspired or expired during normal, quiet...

pulmonary cycle: exhalation

Exhalation and Lung Pressure Changes

Exhalation is the process of expelling air from the lungs. It depends on pressure differences between the lungs and the atmosphere. During normal quiet breathing, exhalation is passive and does not require muscle contraction. The elastic recoil of the lungs and chest wall helps both structures return to their resting positions after inhalation. When the muscles used for inhalation stop working, the diaphragm and external intercostal muscles relax. The diaphragm moves upward, and the ribs move...

factors affecting pulmonary ventilation

What Changes Breathing Ease in the Lungs

Breathing ease in the lungs depends on alveolar surface tension, lung compliance, and airway resistance. These factors affect how hard it is to move air during pulmonary ventilation, along with the pressure difference between the outside environment and the lungs. Alveolar surface tension comes from the fluid lining the inside of the alveoli. Water molecules in this fluid attract each other more strongly than they attract the air, so the liquid tends to pull the alveoli inward. That force must...

respiratory volumes and capacities

Lung Volume Measurements in Breathing

Lung volume measurements show how air moves in and out of the respiratory system during breathing. They help explain how the body takes in oxygen and removes carbon dioxide. Respiratory volumes and capacities also give useful information about lung function. Tidal volume is the air breathed in and out during normal, quiet breathing. Inspiratory reserve volume is the extra air that can be forcefully inhaled beyond tidal volume. Expiratory reserve volume is the extra air that can be forcefully...

physical principles governing gas exchange

physical-principles-governing-gas-exchange

Gas Laws in Lung Gas Exchange

Gas laws explain how oxygen and carbon dioxide move during respiration. External respiration is the exchange of gases in the lungs. Oxygen diffuses into the blood, and carbon dioxide diffuses out. Internal respiration happens in body tissues, where the gases move in the opposite directions. Two gas laws guide this process: Dalton's law of partial pressures and Henry's law. Dalton's law says the total pressure of a gas mixture equals the sum of the pressures of each gas acting alone. The...

external and internal respiration

Gas Exchange in Lungs and Tissues

Gas exchange in the lungs and body tissues moves oxygen into the blood and removes carbon dioxide. External respiration happens in the lungs, where inhaled oxygen enters the alveoli, the tiny air sacs that provide a large surface area for diffusion. Oxygen moves across the thin alveolar membrane into the pulmonary capillaries because its partial pressure is higher in the alveoli than in the blood. At the same time, carbon dioxide moves in the opposite direction and is later breathed out during...

oxygen transport in the blood

How Hemoglobin Loads and Releases Oxygen

Hemoglobin is the main molecule that carries oxygen in blood. It is found in red blood cells and has four polypeptide chains, each attached to an iron-containing heme group. This structure lets one hemoglobin molecule bind up to four oxygen molecules quickly and reversibly. When hemoglobin is fully loaded with oxygen, it is called oxyhemoglobin. When it has released oxygen, it is called reduced hemoglobin, or deoxyhemoglobin. As hemoglobin binds oxygen, its shape changes, which helps it pick...

carbon dioxide transport in the blood

How Blood Carries Carbon Dioxide

Carbon dioxide is carried in the blood from body tissues to the lungs. Cells make about 200 mL of CO2 each minute, and the lungs remove about the same amount. The blood moves this waste gas in three main forms. A small amount, about 7-10%, stays dissolved in the plasma. Just over 20% binds to hemoglobin and forms carbaminohemoglobin. In this case, CO2 attaches to the amino acids of globin, not to the heme part of hemoglobin. The rest, about 70%, is carried as bicarbonate ions, or HCO3-. CO2...

hypoxia

Hypoxia: Types and Carbon Monoxide Poisoning

Hypoxia is a medical condition in which body tissues do not get enough oxygen. It can cause a bluish color in the skin and mucosae, especially in fair-skinned people. This sign is often seen when hemoglobin (Hb) saturation drops below 75%. Hypoxia can happen for several different reasons. Anemic hypoxia occurs when there are too few red blood cells (RBCs) or when RBCs have abnormal or too little Hb. Ischemic hypoxia comes from poor blood circulation or blocked blood flow, so blood becomes...

neural control of respiration

Brainstem Centers That Control Breathing

Breathing is controlled by nerve centers in the brainstem. These respiratory centers send nerve signals to the muscles that move the lungs. The main centers are in the medulla oblongata and the pons.

chemical factors affecting respiration centers

chemical-factors-affecting-respiration-centers

How Blood Gases Control Breathing Rate

Blood gases and blood pH help control breathing rate and depth. Changes in carbon dioxide, oxygen, and hydrogen ion levels in arterial blood are detected by chemoreceptors, which are special sensors in the body. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla. Peripheral chemoreceptors are located in the aortic arch and carotid arteries. Together, these sensors help the respiratory system respond to chemical changes in the blood. Carbon dioxide...

other factors affecting respiration centers

other-factors-affecting-respiration-centers

Respiratory Reflexes That Change Breathing

Breathing is controlled by the brainstem, but it can also be changed by the nervous system and by body signals. The cerebral motor cortex can override the medullary respiratory centers and send signals directly to the breathing muscles. This makes voluntary actions like holding your breath or taking deeper breaths possible. That control is limited. When carbon dioxide, or CO2, builds up in the blood to a critical level, the brainstem respiratory centers start breathing again. This is why a...

hyperpnea and hyperventilation

Breathing Changes in Exercise and Anxiety

Breathing changes in exercise and anxiety can look similar, but they do not have the same cause. Hyperventilation is a higher-than-normal rate and depth of breathing. It often happens during anxiety attacks and can push out more carbon dioxide than the body needs to remove. When too much carbon dioxide is lost, the blood develops hypocapnia, which means an unusually low level of carbon dioxide. Hypocapnia can narrow cerebral blood vessels and reduce blood flow to the brain. This may cause...

chronic obstructive pulmonary disease

COPD Signs, Causes, and Lung Damage

COPD is a lung condition that causes ongoing breathing problems. It leads to shortness of breath, cough, and sputum production because the airways become blocked and airflow is reduced. Smoking is the main risk factor for COPD, and more than 80% of patients have a history of it. People with COPD often develop worsening dyspnea, or labored breathing. They may also cough often and get repeated lung infections. Many patients with COPD can develop respiratory failure. This happens when...

other pulmonary disorders

Asthma, TB, Lung Cancer, and Sleep Apnea

Asthma, lung cancer, tuberculosis, and sleep apnea are major pulmonary disorders. They affect breathing in different ways. Some are chronic, some are infectious, and some can become life-threatening if not found and treated early. Asthma is marked by chronic airway inflammation and hypersensitivity. It can cause airway obstruction from bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Triggers vary and can include allergens or emotional upset. Treatment often...

key terms and concepts

Explore pulmonary ventilation, lung volumes, and the pressure changes that drive inhalation, including the diaphragm, intercostal muscles, and key breathing pressures.

Pulmonary Ventilation and Breathing Pressures | JoVE K12

anatomy and physiology

JoVE Core 解剖学と生理学では、人体の解剖学的および生理学的な詳細を、包括的で明確で魅力的なビデオ アニメーションで紹介します。このレッスン集は、人体の構造、コンポーネント、機能、要件に焦点を当てています。この知識を実際の医療および研究現場で応用することを実証する科学者による実際のビデオによって補完されています。

Alabama Course of Study Science

from-molecules-to-organisms-structures-and-processes

From Molecules to Organisms: Structures and Processes

9-12.HA.1.9.b

Florida Department of Education

High School

Life Science

SC.912.L.14

SC.912.L.14.44

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Peritoneum

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The large intestine, a vital component of the gastrointestinal tract, is structured with four main layers: the mucosa, submucosa, muscularis, and serosa. ...

Gallbladder

The gallbladder is a muscular sac located in a shallow fossa on the inferior surface of the liver. It measures about 10 cm in length and is roughly the ...

Bacterial Flora of the Large

Intestine

The vast and varied community of bacteria colonizing the large intestine forms the gut microbiome.
Bacteria start residing in the gut at birth and ...

Liver Physiology

Liver functions primarily include bile production, metabolic regulation, and hematological functions.
During carbohydrate metabolism, the liver regulates ...

digestive-functions-of-the-large-intestine

Digestive Functions of the Large Intestine

The final stages of digestion occur in the large intestine when the cecum receives chyme, which has little nutritional value except for the indigestible ...

Absorption of Nutrients

During digestion in the small intestine, macromolecules&#8212; carbohydrates, proteins, and fats &#8212; are broken down into their simplest forms.
These ...

Feces Formation and Defecation

After spending 3 to 10 hours in the large intestine, chyme loses a lot of water and becomes feces, the final product of digestion. Feces consist of ...

Other Disorders of Digestive System

The gastrointestinal tract of the digestive system is susceptible to various disorders.
The incompetence of the lower esophageal sphincter results in the ...

Digestive System

Content elaboration: The digestive system consists of the gastrointestinal tract (alimentary canal) as well as various accessory organs including the teeth, tongue, salivary glands, liver, gallbladder and pancreas. The digestive system processes and supplies the molecules needed to sustain the living tissues within the body through the absorption of nutrients. Six major functions of the digestive system include secretion, ingestion, mechanical processing, enzymatic digestion, absorption and excretion. The lining of the digestive system protects surrounding tissues from the mechanical and enzymatic stresses of the digestive process. Processes of the digestive system include the mechanical and chemical breakdown of food into small molecules which are then absorbed by the digestive tract. Specific actions within the digestive system include mastication, peristalsis, segmentation and the release of hormones and enzymes necessary for digestion. The metabolic functions of the accessory organs play strategic roles in the breakdown of food products, the maintenance of glucose levels within the blood and the regulation of homeostasis in the body. Indigestible material is excreted as waste. Homeostatic imbalances are explored. These include, but are not limited to, conditions such as gallstones, heartburn, ulcers, dehydration, diarrhea, cirrhosis and cancers of the digestive system. Investigations are used to understand and explain the digestive system in a variety of inquiry and design scenarios that can incorporate evolutionary concepts, scientific reasoning, comparative analysis, communication skills and real-world applications.

Digestive System

Pulmonary Ventilation and Breathing Pressures

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