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Split-and-Pool-Synthese und Charakterisierung von Peptid-Amid-Tertiär-Bibliothek
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Split-and-Pool-Synthese und Charakterisierung von Peptid-Amid-Tertiär-Bibliothek

Article DOI: 10.3791/51299-v • 13:37 min • June 20th, 2014
June 20th, 2014 •
1, 1
1Scripps Florida, The Scripps Research Institute

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Peptid tertiäre Amide (PTA) sind eine Superfamilie von Peptidmimetika umfassen, sind aber nicht auf Peptide, Peptoide und N-methylierten Peptide beschränkt. Hier beschreiben wir eine Synthesemethode, die sowohl Split-and-Pool-und Sub-Monomer-Strategien kombiniert, um eine ein-Bead-one-Verbindung Bibliothek von PTAs synthetisieren.

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Chemie Heft 88 Split-and-Pool-Synthese Peptid tertiäres Amid PTA Peptoids Hochdurchsatz-Screening kombinatorische Bibliothek feste Phase Triphosgen (BTC) ein-Wulst-Verbindung ein OBOC
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