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Een High Throughput MHC II Bindingsassay voor de kwantitatieve analyse van peptide-epitopen
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Een High Throughput MHC II Bindingsassay voor de kwantitatieve analyse van peptide-epitopen

Article DOI: 10.3791/51308-v • 07:59 min • March 25th, 2014
March 25th, 2014 •
1, 2, 3, 1
1Thayer School of Engineering, Dartmouth College, 2Institute for Immunology and Informatics, University of Rhode Island, 3Department of Computer Science, Dartmouth College

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Biochemische analyses met recombinant humaan MHC II moleculen kunnen bieden snelle, kwantitatieve inzichten in immunogeen epitoop identificatie, verwijdering, of ontwerp. Hier wordt een peptide-MHC bindingstest geschaald naar 384-well platen beschreven. Deze kosteneffectieve formaat moet nuttig zijn in het gebied van eiwit deimmunization en vaccin ontwerp en ontwikkeling te bewijzen.

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Biochemie Immunoassay Protein immunogeniciteit MHC II T-cel epitoop High Throughput Screen Deimmunization Vaccine Ontwerp
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