Waiting
로그인 처리 중...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Biochemistry / Metod för att identifiera små molekylhämmare av…
JoVE Journal
Biochemistry

JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.

JoVE Journal Biochemistry
Metod för att identifiera små molekylhämmare av protein-proteininteraktion Mellan HCN1 och TRIP8b
Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
Journal (Biochemistry)
Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
Arteriovenous Blood Sampling Technique in Mice Using Sulzer's Vein and Left Ventricle for Metabolomic Analysis (Video) | JoVE
Journal (Biochemistry)
Arteriovenous Blood Sampling Technique in Mice Using Sulzer's Vein and Left Ventricle for Metabolomic Analysis (Video) | JoVE
 
Click here for the English version

Metod för att identifiera små molekylhämmare av protein-proteininteraktion Mellan HCN1 och TRIP8b

Article DOI: 10.3791/54540-v • 10:20 min • November 11th, 2016
November 11th, 2016 •
*1, *1, 2, 3, 1, 1, 4, 1,5
1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, 2Center for Molecular Innovation and Drug Discovery, Northwestern University, 3Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, 5Department of Physiology, Feinberg School of Medicine, Northwestern University
* These authors contributed equally

챕터

요약
Automatic Translation

Please note that all translations are automatically generated.

Click here for the English version.

Samspelet mellan HCN kanaler och deras hjälp subenhet har identifierats som ett terapeutiskt mål i egentlig depression. Här, en fluorescenspolariserings-baserad metod för att identifiera småmolekylära hämmare av detta protein-proteininteraktion, presenteras.

Tags

Biokemi High-throughput screening läkemedelsutveckling protein-proteininteraktioner fluorescenspolarisation HCN TRIP8b
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter